Department of Gastroenterology, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China.
Department of Gastroenterology, Xiangya Hospital, Central South University, #87 Xiangya Road, Changsha, Hunan 410008, China.
Clin Res Hepatol Gastroenterol. 2023 Nov;47(9):102214. doi: 10.1016/j.clinre.2023.102214. Epub 2023 Sep 24.
Crohn's disease (CD) and ulcerative colitis (UC) are the main representatives of inflammatory bowel disease (IBD), which is a chronic, relapsing inflammatory disease of the gastrointestinal tract mediated by the immune system. The pathogenesis of IBD is still not fully clarified. Currently, several studies have reported that circadian abnormality has profound effects on the immune system and intestinal microflora. Meanwhile, it is widely accepted that immune function and intestinal microbiota are two major factors in the pathogenesis of IBD. However, the role of the circadian rhythm in relation to IBD is relatively less understood and largely unexplored. The aim of this review is to present the current state of knowledge about the relationship between circadian rhythm disorders, sleep disturbance, and IBD to analyze the possibility of employing this knowledge in IBD diagnosis and treatment.
克罗恩病（CD）和溃疡性结肠炎（UC）是炎症性肠病（IBD）的主要代表，是一种由免疫系统介导的慢性、复发性胃肠道炎症性疾病。IBD 的发病机制尚不完全清楚。目前，一些研究报道称，昼夜节律异常对免疫系统和肠道微生物群有深远影响。同时，人们普遍认为，免疫功能和肠道微生物群是 IBD 发病机制的两个主要因素。然而，关于昼夜节律与 IBD 的关系的作用相对较少被理解和探索。本综述旨在介绍目前关于昼夜节律紊乱、睡眠障碍与 IBD 之间关系的知识状况，分析将这些知识应用于 IBD 诊断和治疗的可能性。
