cGAS-STING 信号通路在肿瘤微环境中的作用。
cGAS-STING signaling in the tumor microenvironment.
机构信息
NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China.
Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China.
出版信息
Cancer Lett. 2023 Nov 28;577:216409. doi: 10.1016/j.canlet.2023.216409. Epub 2023 Sep 23.
The cGAS-STING signaling is an important pathway involved in the regulation of tumor microenvironment, which affects many cellular functions including immune activation. Its role in combating tumor progression is widely recognized, especially with its function in inducing innate and adaptive immune responses, on which many immunotherapies have been developed. However, a growing number of findings also suggest a diversity of its roles in shaping tumor microenvironment, including functions that promote tumor progression. Here, we summarize the functions of the cGAS-STING signaling in tumor microenvironment to maintain tumor survival and proliferation through facilitating the forming of an immunosuppressive tumor microenvironment and discuss the current advances of STING-related immunotherapies.
cGAS-STING 信号通路是参与肿瘤微环境调控的重要途径，它影响许多细胞功能，包括免疫激活。其在抑制肿瘤进展方面的作用已得到广泛认可，尤其是在诱导先天和适应性免疫反应方面，许多免疫疗法都以此为基础。然而，越来越多的研究结果表明，cGAS-STING 信号通路在塑造肿瘤微环境方面具有多样性，包括促进肿瘤进展的功能。在这里，我们总结了 cGAS-STING 信号通路在肿瘤微环境中的作用，通过促进免疫抑制性肿瘤微环境的形成来维持肿瘤的存活和增殖，并讨论了与 STING 相关的免疫疗法的最新进展。
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