Tabriz Health Services Management Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of General and Minimally Invasive surgery, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
BMC Endocr Disord. 2023 Sep 25;23(1):205. doi: 10.1186/s12902-023-01459-3.
Existing research provides conflicting evidence regarding the relationship between estimated branched-chain amino acid (BCAA) intake and metabolic, glycemic markers, and anthropometric characteristics. This research seeks to examine the association between estimated dietary BCAA consumption and glycemic, and metabolic markers, as well as anthropometric parameters in adults classified as overweight or obese.
In this cross-sectional analysis, we gathered data from 465 overweight and obese individuals aged between 18 and 37 years. To evaluate dietary data, we employed the food frequency questionnaire, and the BCAA content in foods was determined via the United States Department of Agriculture website. We utilized ELISA kits to measure fasting blood glucose (FBS) and lipid profile markers, and additionally calculated low-density lipoprotein (LDL) and insulin sensitivity markers. We assessed sociodemographic status, physical activity (PA), and anthropometric attributes through a method recognized as both valid and reliable. For statistical analysis, we conducted analyses of covariance (ANCOVA), making adjustments for variables including sex, PA, age, energy, and body mass index (BMI).
Upon adjusting for confounders, those in the highest tertiles of BCAA intake exhibited an increase in weight, BMI, waist circumference (WC), waist-to-hip ratio (WHR), and fat-free mass (FFM). Conversely, they demonstrated reduced fat mass (FM) (%) and FM (kg) compared to their counterparts in the lowest tertiles (P < 0.05). Additionally, there was a noted association between greater estimated BCAA intake and reduced LDL levels. Nonetheless, our findings did not reveal a significant relationship between dietary BCAA and glycemic indices.
From our findings, an increased estimated intake of BCAA seems to correlate with diminished serum LDL concentrations. To gain a more comprehensive understanding of this association, it is imperative that further experimental and longitudinal studies be conducted.
现有研究提供了相互矛盾的证据，表明支链氨基酸（BCAA）摄入量与代谢、血糖标志物和人体测量特征之间的关系。本研究旨在检查超重或肥胖成年人中估计的饮食 BCAA 消耗与血糖和代谢标志物以及人体测量参数之间的关联。
在这项横断面分析中，我们收集了 465 名年龄在 18 至 37 岁之间的超重和肥胖个体的数据。为了评估饮食数据，我们使用了食物频率问卷，通过美国农业部网站确定食物中的 BCAA 含量。我们使用 ELISA 试剂盒测量空腹血糖（FBS）和血脂谱标志物，并且还计算了低密度脂蛋白（LDL）和胰岛素敏感性标志物。我们通过一种既有效又可靠的方法评估了社会人口统计学状况、身体活动（PA）和人体测量属性。对于统计分析，我们进行了协方差分析（ANCOVA），并对性别、PA、年龄、能量和体重指数（BMI）等变量进行了调整。
在调整了混杂因素后，BCAA 摄入量最高三分位的人体重、BMI、腰围（WC）、腰臀比（WHR）和去脂体重（FFM）增加。相比之下，与最低三分位的人相比，他们的脂肪量（FM）（%）和 FM（kg）减少（P<0.05）。此外，较高的估计 BCAA 摄入量与较低的 LDL 水平之间存在关联。尽管如此，我们的研究结果并未显示饮食 BCAA 与血糖指数之间存在显著关系。
根据我们的研究结果，BCAA 的估计摄入量增加似乎与血清 LDL 浓度降低有关。为了更全面地了解这种关联，必须进行进一步的实验和纵向研究。
