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中国强迫症、焦虑症、抑郁症患者与非临床对照人群中“不适感体验”的比较

A comparison of 'not just right experiences' in obsessive-compulsive disorder, anxiety and depressive disorders and non-clinical controls in China.

作者信息

Yang Lijuan, Chen Daning, Zhang Xiaodong, Huang Fangfang, Li Zhanjiang, Yang Xiangyun

机构信息

Department of Clinical Psychology, Beijing Anding Hospital, National Clinical Research Center for Mental Disorders, Capital Medical University, Beijing, China.

Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.

出版信息

Clin Psychol Psychother. 2023 Sep 25. doi: 10.1002/cpp.2916.

Abstract

OBJECTIVE

The aim of this study is to investigate the characteristics of 'not just right experiences' (NJREs) in patients with obsessive-compulsive disorder (OCD), anxiety disorders (ADs) or major depressive disorder (MDD), compared with those of healthy controls (HCs).

METHOD

One hundred adults with OCD, 86 adults with ADs, 57 adults with MDD and 60 HCs were enrolled in the study. The Not Just Right Experiences Questionnaire Revised (NJRE-QR), Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were used to evaluate clinical symptoms in patients with OCD, ADs or MDD. The Obsessive Belief Questionnaire-44 (OBQ-44) was used to evaluate OC beliefs in the OCD patients. The HCs only received assessment using the NJRE-QR. Analysis of variance (ANOVA) and covariance (ANCOVA) were performed to compare the NJREs scores across the groups, while Pearson correlation and partial correlation analyses were used to examine the association between NJREs and other clinical features. The contribution of NJREs to predict OC symptoms was determined by multiple stratified linear regression.

RESULTS

Individuals with OCD had significantly higher scores for the number of NJREs than ADs, but not MDD. The severity of NJREs was also significantly higher in patients with OCD than those with MDD or ADs (F = 5.23 and F = 19.79, respectively, P < 0.01). All the clinical scores in the NJRE-QR were significantly higher than those in the HC group. The number and severity of NJREs correlated significantly with the Y-BOCS total score (r = 0.29 and r = 0.39, respectively, P < 0.01). NJREs showed an independent contribution to OC symptoms, which alone explained 8% of the variation (F = 16.49, ΔR  = 0.08; P < 0.01).

CONCLUSION

NJREs are related closely to OC symptoms, with their severity discriminating between OCD patients and those with ADs or MDD. NJREs were more specific for OCD in the Chinese population and are therefore worthy of further study in the future.

摘要

目的

本研究旨在调查强迫症(OCD)、焦虑症(ADs)或重度抑郁症(MDD)患者中“不恰到好处体验”(NJREs)的特征,并与健康对照者(HCs)进行比较。

方法

本研究纳入了100名患有强迫症的成年人、86名患有焦虑症的成年人、57名患有重度抑郁症的成年人以及60名健康对照者。使用修订后的不恰到好处体验问卷(NJRE-QR)、耶鲁-布朗强迫症量表(Y-BOCS)、贝克抑郁量表(BDI)和贝克焦虑量表(BAI)来评估强迫症、焦虑症或重度抑郁症患者的临床症状。使用强迫信念问卷-44(OBQ-44)来评估强迫症患者的强迫信念。健康对照者仅接受NJRE-QR评估。进行方差分析(ANOVA)和协方差分析(ANCOVA)以比较各组的NJREs得分,同时使用Pearson相关分析和偏相关分析来检验NJREs与其他临床特征之间的关联。通过多重分层线性回归确定NJREs对预测强迫症状的贡献。

结果

强迫症患者的NJREs数量得分显著高于焦虑症患者,但不高于重度抑郁症患者。强迫症患者的NJREs严重程度也显著高于重度抑郁症或焦虑症患者(F分别为5.23和19.79,P<0.01)。NJRE-QR中的所有临床得分均显著高于健康对照组。NJREs的数量和严重程度与Y-BOCS总分显著相关(r分别为0.29和0.39,P<0.01)。NJREs对强迫症状有独立贡献,其单独解释了8%的变异(F=16.49,ΔR=0.08;P<0.01)。

结论

NJREs与强迫症状密切相关,其严重程度可区分强迫症患者与焦虑症或重度抑郁症患者。NJREs在中国人群中对强迫症更具特异性,因此未来值得进一步研究。

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