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一名55岁慢性下腰痛女性的普瑞巴林依赖及处理

Pregabalin Dependence and Management in a 55-Year-Old Female with Chronic Low Back Pain.

作者信息

Vasudeva Abhimanyu, Tripathi Richa

机构信息

Physical Medicine and Rehabilitation, All India Institute of Medical Sciences, Gorakhpur, Gorakhpur, IND.

Psychiatry, All India Institute of Medical Sciences, Gorakhpur, Gorakhpur, IND.

出版信息

Cureus. 2023 Aug 25;15(8):e44085. doi: 10.7759/cureus.44085. eCollection 2023 Aug.

DOI:10.7759/cureus.44085
PMID:37750123
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10518057/
Abstract

This case report explores the complexities of managing chronic pain and the subsequent development of pregabalin dependence in a 55-year-old female patient with a prior history of vertebral fracture. Over a period of 10 years, the patient relied on a combination of Aceclofenac and pregabalin to alleviate her pain. An alternative treatment approach was implemented, involving adjustments to medication dosages and gradual tapering. Throughout the treatment process, interdisciplinary collaboration played a pivotal role in addressing unexpected symptoms such as facial movements and neck swelling. This case report highlights the significance of recognizing and addressing pregabalin dependence in patients with chronic pain.

摘要

本病例报告探讨了一名有椎体骨折病史的55岁女性患者在管理慢性疼痛及随后出现普瑞巴林依赖方面的复杂性。在10年的时间里,该患者依靠双氯芬酸和普瑞巴林的联合使用来缓解疼痛。实施了一种替代治疗方法,包括调整药物剂量和逐渐减药。在整个治疗过程中,跨学科协作在处理如面部运动和颈部肿胀等意外症状方面发挥了关键作用。本病例报告强调了认识和处理慢性疼痛患者中普瑞巴林依赖的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34df/10518057/4decb0977daf/cureus-0015-00000044085-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34df/10518057/4decb0977daf/cureus-0015-00000044085-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34df/10518057/4decb0977daf/cureus-0015-00000044085-i01.jpg

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本文引用的文献

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Trends in gabapentinoid prescribing in UK primary care using the Clinical Practice Research Datalink: an observational study.利用临床实践研究数据链分析英国初级保健中加巴喷丁类药物的处方趋势:一项观察性研究。
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Gabapentinoid Benefit and Risk Stratification: Mechanisms Over Myth.加巴喷丁类药物的获益与风险分层:摒弃神话,基于机制
Pain Ther. 2020 Dec;9(2):441-452. doi: 10.1007/s40122-020-00189-x. Epub 2020 Jul 31.
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Use of Gabapentin in the Treatment of Substance Use and Psychiatric Disorders: A Systematic Review.加巴喷丁在物质使用和精神障碍治疗中的应用:一项系统综述。
Front Psychiatry. 2019 May 7;10:228. doi: 10.3389/fpsyt.2019.00228. eCollection 2019.
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Gabapentin use, abuse, and the US opioid epidemic: the case for reclassification as a controlled substance and the need for pharmacovigilance.加巴喷丁的使用、滥用与美国阿片类药物流行:重新归类为管制药物的理由及药物警戒的必要性
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How addictive are gabapentin and pregabalin? A systematic review.加巴喷丁和普瑞巴林的成瘾性如何?系统评价。
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