小鼠胸腺的低温保存会耗尽胸腺细胞，但支持移植后的免疫重建。
Cryopreservation of mouse thymus depletes thymocytes but supports immune reconstitution on transplantation.
机构信息
UCL Great Ormond Street Institute of Child Health, London, UK.
Cytiva, Danaher Corporation, Cambridge, UK.
出版信息
Eur J Immunol. 2023 Dec;53(12):e2350546. doi: 10.1002/eji.202350546. Epub 2023 Oct 17.
Abstract
Cryopreservation of mouse thymus depletes donor thymocytes but preserves thymus function when transplanted after thawing into athymic mice. No differences in immune reconstitution were observed between fresh and frozen/thawed transplants suggesting that donor thymocyte depletion does not affect outcome. Thus, cryopreservation of thymus may improve outcomes in thymus transplant patients.
摘要
将小鼠胸腺进行冷冻保存可在解冻后移植到无胸腺小鼠中时耗尽供体胸腺细胞，但保留胸腺功能。新鲜和冷冻/解冻移植之间的免疫重建没有差异，这表明供体胸腺细胞耗竭不会影响结果。因此，胸腺的冷冻保存可能会改善胸腺移植患者的预后。
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