Jha Ameet Kumar, Nauhria Samal, Maity Sabyasachi
Department of Anatomical Sciences, St. Matthew's University School of Medicine, Georgetown, Cayman Islands.
Department of Pathology, St. Matthew's University School of Medicine, Georgetown, Cayman Islands.
Anat Cell Biol. 2023 Dec 31;56(4):584-587. doi: 10.5115/acb.23.179. Epub 2023 Sep 27.
Polymelia is an extremely rare congenital anomaly where an individual is born with an abnormally developed extra or supernumerary limb which is generally shrunken and functionless. A case of thoracomelia (a type of polymelia) was observed macroscopically and confirmed radiologically in 1.5 years old boy born in Nepal with an abnormal supernumerary upper limb attached to his back in the thoracic region. The limb was successfully amputated, and the boy had a favorable outcome after surgical treatment, without any adverse effects or impairment. Understanding the embryogenesis of thoracomelia is essential for unraveling the complex mechanisms underlying this condition and potentially aiding in early diagnosis and intervention. This case report and review aims to shed light on the intricate processes governing forelimb formation and their perturbations leading to thoracomelia.
多肢畸形是一种极其罕见的先天性异常，即个体出生时带有发育异常的多余肢体，通常萎缩且无功能。在一名出生于尼泊尔的1.5岁男孩身上，肉眼观察到并经放射学确认了一例胸段多肢畸形（多肢畸形的一种类型），其胸部区域的背部附着有一个异常的多余上肢。该肢体成功进行了截肢手术，男孩术后恢复良好，未出现任何不良反应或功能障碍。了解胸段多肢畸形的胚胎发生对于阐明这种疾病背后的复杂机制以及可能有助于早期诊断和干预至关重要。本病例报告及综述旨在阐明控制前肢形成的复杂过程及其导致胸段多肢畸形的扰动。
