Department of Clinical and Experimental Sciences, SSD Endocrinologia, University of Brescia, ASST Spedali Civili of Brescia, Piazzale Spedali Civili no 1, 25100, Brescia, Italy.
UOC Medicina Generale ad Indirizzo Metabolico e Diabetologico, ASST Spedali Civili of Brescia, Brescia, Italy.
J Endocrinol Invest. 2024 Apr;47(4):857-864. doi: 10.1007/s40618-023-02200-6. Epub 2023 Sep 26.
To characterize patients with APS and to propose a new approach for their follow-up. Query ID="Q1" Text="Please check the given names and familynames."
Monocentric observational retrospective study enrolling patients referred to the Outpatients clinic of the Units of Endocrinology, Diabetology, Gastroenterology, Rheumatology and Clinical Immunology of our Hospital for Autoimmune diseases.
Among 9852 patients, 1174 (11.9%) [869 (73.9%) female] were diagnosed with APS. In 254 subjects, the diagnosis was made at first clinical evaluation (Group 1), all the other patients were diagnosed with a mean latency of 11.3 ± 10.6 years (Group 2). Group 1 and 2 were comparable for age at diagnosis (35.7 ± 16.3 vs. 40.4 ± 16.6 yrs, p = .698), but different in male/female ratio (81/173 vs 226/696, p = .019). In Group 2, 50% of patients developed the syndrome within 8 years of follow-up. A significant difference was found after subdividing the first clinical manifestation into the different outpatient clinic to which they referred (8.7 ± 8.0 vs. 13.4 ± 11.6 vs. 19.8 ± 8.7 vs. 7.4 ± 8.1 for endocrine, diabetic, rheumatologic, and gastroenterological diseases, respectively, p < .001).
We described a large series of patients affected by APS according to splitters and lumpers. We propose a flowchart tailored for each specialist outpatient clinic taking care of the patients. Finally, we recommend regular reproductive system assessment due to the non-negligible risk of developing premature ovarian failure.
对 APS 患者进行特征分析，并提出新的随访方法。查询 ID="Q1" 文本="请核对姓名。"
这是一项单中心观察性回顾性研究，纳入了因自身免疫性疾病在我院内分泌、糖尿病、胃肠病、风湿病和临床免疫学门诊就诊的患者。
在 9852 名患者中，1174 名（11.9%）[869 名（73.9%）为女性]被诊断为 APS。254 名患者在首次临床评估时做出诊断（1 组），其余所有患者的诊断潜伏期平均为 11.3±10.6 年（2 组）。1 组和 2 组在诊断年龄方面具有可比性（35.7±16.3 岁比 40.4±16.6 岁，p=0.698），但在男女比例方面存在差异（81/173 比 226/696，p=0.019）。2 组中有 50%的患者在随访 8 年内出现该综合征。将首发临床表现进一步细分为就诊的不同门诊科室后，差异有统计学意义（分别为内分泌、糖尿病、风湿病和胃肠病门诊为 8.7±8.0 岁、13.4±11.6 岁、19.8±8.7 岁和 7.4±8.1 岁，p<0.001）。
我们根据拆分器和分组器对受 APS 影响的患者进行了大型系列描述。我们为每个负责患者的专科门诊量身定制了流程图。最后，我们建议定期进行生殖系统评估，因为发生卵巢早衰的风险不可忽视。
