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特应性皮炎对年轻人职业性接触性皮炎的影响:一项回顾性队列研究。

Impact of atopic dermatitis on occupational contact dermatitis among young people: A retrospective cohort study.

机构信息

Department of Dermato-Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, Hellerup, Denmark.

University of Copenhagen, Copenhagen, Denmark.

出版信息

Contact Dermatitis. 2024 Feb;90(2):143-152. doi: 10.1111/cod.14426. Epub 2023 Sep 26.

Abstract

BACKGROUND

Occupational contact dermatitis (OCD) is a common occupational disease. Atopic dermatitis (AD) is a known risk factor for OCD.

OBJECTIVES

To determine the prevalence of previously diagnosed AD among young workers with recognized OCD and assess its impact on OCD prognosis.

METHODS

A retrospective cohort study. A questionnaire was sent to 6251 workers with recognized OCD who were under 35 years at notification (response rate: 47%). Of the respondents, 2392 answered a question about previous doctor-diagnosed AD and were included in the study. Eczema severity, occupational consequences and quality of life were examined using statistical analyses comparing workers with and without previously diagnosed AD.

RESULTS

The prevalence of previously diagnosed AD was 41.8% (95% CI: 39.8-43.8). Women had a higher AD prevalence, and workers with AD reported OCD at a younger age. Workers with AD reported more frequent and severe eczema symptoms and had a higher risk of OCD negatively affecting job and occupation choices. Health-related quality of life was more adversely affected in workers with AD.

CONCLUSIONS

AD significantly impacts severity and has long-term consequences for young people with OCD. Targeted prevention strategies need to be developed.

摘要

背景

职业性接触性皮炎(OCD)是一种常见的职业病。特应性皮炎(AD)是 OCD 的已知危险因素。

目的

确定已确诊的 OCD 年轻患者中先前诊断出的 AD 的患病率,并评估其对 OCD 预后的影响。

方法

回顾性队列研究。向 6251 名在通知时年龄在 35 岁以下的已确诊 OCD 工人发送了一份问卷(回应率:47%)。在回答者中,有 2392 人回答了关于先前医生诊断的 AD 的问题,并纳入了研究。使用统计分析比较了有和没有先前诊断的 AD 的工人,以检查湿疹严重程度、职业后果和生活质量。

结果

先前诊断的 AD 的患病率为 41.8%(95%CI:39.8-43.8)。女性的 AD 患病率更高,且患有 AD 的工人发病年龄更早。患有 AD 的工人报告更频繁和更严重的湿疹症状,并且 OCD 对工作和职业选择的负面影响的风险更高。AD 患者的健康相关生活质量受到更大的影响。

结论

AD 显著影响严重程度,并对患有 OCD 的年轻人产生长期后果。需要制定有针对性的预防策略。

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