一名接受硫嘌呤和抗TNF治疗的克罗恩病患者发生原发性肝淋巴瘤：病例报告
A primary hepatic lymphoma in a patient with Crohn's disease receiving thiopurine and anti-TNF therapy: a case report.
作者信息
Merhaben Salma, Ayadi Shema, Tangour Monia, Boujelbene Nadia, Ghariani Rayfa, Mouelhi Leila, Merhaben Fathi
机构信息
Gastroenterology Department, Charles Nicolle hospital, Tunis, 1006, Tunisia.
Histopathology Department, Salah Azaiez Institute, Tunis, 1007, Tunisia.
出版信息
Future Sci OA. 2023 Aug 28;9(10):FSO893. doi: 10.2144/fsoa-2023-0082. eCollection 2023 Dec.
Primary hepatic lymphoma is a rare variant of non-Hodgkin's lymphoma with an incidence of 0.016% of all non-Hodgkin lymphomas. The most common histologic subtype is large diffuse B-cell lymphoma. Pathogenesis is not clearly established and undergoing immunosuppressive therapy has been proposed as a risk factor for primary hepatic lymphoma. We report an intriguing case study, featuring a 23-year-old male patient with Crohn's Disease who had been receiving a combination therapy of thiopurine and anti-TNF for 6 years and was diagnosed with primary hepatic diffuse large B-cell lymphoma.
原发性肝淋巴瘤是一种罕见的非霍奇金淋巴瘤变体，占所有非霍奇金淋巴瘤的0.016%。最常见的组织学亚型是弥漫性大B细胞淋巴瘤。其发病机制尚未明确，有人提出接受免疫抑制治疗是原发性肝淋巴瘤的一个危险因素。我们报告了一个有趣的病例研究，患者为一名23岁的克罗恩病男性，接受硫嘌呤和抗TNF联合治疗6年，被诊断为原发性肝弥漫性大B细胞淋巴瘤。
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