Qiu Meng-Jun, Fang Xie-Fan, Huang Zao-Zao, Li Qiu-Ting, Wang Meng-Meng, Jiang Xin, Xiong Zhi-Fan, Yang Sheng-Li
Division of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, China.
Charles River Laboratories, Inc., 6995 Longley Lane, Reno, NV 89511, United States.
Transl Oncol. 2021 Jan;14(1):100931. doi: 10.1016/j.tranon.2020.100931. Epub 2020 Nov 11.
Primary hepatic lymphoma (PHL) is a rare malignancy with lesions confined to the liver. It is characterized by a large number of monomorphic, medium-sized lymphocytic infiltrates in the hepatic sinusoid. Due to the rarity of this malignancy, our current understanding of PHL is limited.
We collected incidence, mortality, and clinical data of PHL patients diagnosed between 1975 and 2016 using the Surveillance, Epidemiology, and End Results (SEER) database. The annual percentage changes (APCs) and prognoses were analyzed using the Joinpoint and R package.
Among the 1,372 patients, white males were prevalent, and the most common histological subtype was diffuse large B-cell lymphoma (DLBCL). The incidence and mortality rate of PHL was 0.075/100,000 person-years and 0.055/100,000 person-years, respectively. The annual incidence rate of PHL increased significantly, with an APC of 2.74% (P < 0.001). The 3- and 5-year overall survival (OS) rates of patients with PHL were 43.553% and 39.242%, respectively. The 3- and 5-year relative survival (RS) rates were 46.925% and 45.300%, respectively. Multivariate Cox regression analysis revealed that older age, black, DLBCL, and advanced-stage disease were independent predictors of unfavorable OS and RS. The C-index and receiver operating characteristic (ROC) analysis confirmed the prognostic value of the nomograms established in this study.
The nomogram established in this study is a robust tool to predict the prognosis of PHL patients.
原发性肝淋巴瘤（PHL）是一种罕见的恶性肿瘤，病变局限于肝脏。其特征是肝血窦中有大量单形性、中等大小的淋巴细胞浸润。由于这种恶性肿瘤罕见，我们目前对PHL的了解有限。
我们使用监测、流行病学和最终结果（SEER）数据库收集了1975年至2016年期间诊断的PHL患者的发病率、死亡率和临床数据。使用Joinpoint和R软件包分析年度百分比变化（APC）和预后。
在1372例患者中，白人男性居多，最常见的组织学亚型是弥漫性大B细胞淋巴瘤（DLBCL）。PHL的发病率和死亡率分别为0.075/10万/人年和0.055/10万/人年。PHL的年发病率显著上升，APC为2.74%（P<0.001）。PHL患者的3年和5年总生存率（OS）分别为43.553%和39.242%。3年和5年相对生存率（RS）分别为46.925%和45.300%。多变量Cox回归分析显示，年龄较大、黑人、DLBCL和晚期疾病是OS和RS不良的独立预测因素。C指数和受试者工作特征（ROC）分析证实了本研究建立的列线图的预后价值。
本研究建立的列线图是预测PHL患者预后的有力工具。
