Segal S S, Duling B R
Science. 1986 Nov 14;234(4778):868-70. doi: 10.1126/science.3775368.
Optimal distribution of blood flow requires coordination of vasodilation among resistance vessels. During hyperemia, blood vessels dilate upstream from the initiating stimulus. Spreading vasodilation independent of flow changes has not been previously demonstrated. In the present study, iontophoresis of acetylcholine adjacent to single hamster cheek pouch arterioles in situ (diameter, 20 to 37 micrometers) induced a rapid bidirectional dilation that was not attenuated when blood flow was eliminated with vascular occlusion. This finding indicates that a vasodilatory stimulus is conducted along the arteriole and demonstrates the existence of a mechanism of intercellular communication that is capable of coordinating diameter changes among resistance vessels.
最佳血流分布需要阻力血管之间的血管舒张协调。在充血期间，血管在起始刺激的上游扩张。此前尚未证明存在与血流变化无关的扩展性血管舒张。在本研究中，对原位单个仓鼠颊囊小动脉（直径20至37微米）旁进行乙酰胆碱离子电渗疗法，可诱导快速双向扩张，当通过血管闭塞消除血流时，这种扩张并未减弱。这一发现表明血管舒张刺激沿小动脉传导，并证明存在一种能够协调阻力血管直径变化的细胞间通讯机制。
