Winson J, Dahl D
Science. 1986 Nov 21;234(4779):985-8. doi: 10.1126/science.3775372.
Long-term potentiation (LTP), a long-lasting enhancement of synaptic efficacy, is considered a model for learning and memory. In anesthetized rats, activation of dentate granule cells by stimulating either the medial or lateral perforant pathway at frequencies of 100 to 400 Hz produced LTP of the stimulated pathway preferentially at 400 Hz. However, hippocampal pathways do not normally fire at this high rate. Stimuli at 200 Hz were then applied to either the medial or lateral pathway separately, to both pathways simultaneously, or to the two pathways asynchronously so that the composite stimulus applied to the granule cell dendrite was 400 Hz. LTP was produced preferentially in the asynchronous condition. Thus, lower frequency, physiological input volleys arriving asynchronously at medial and lateral synapses can induce LTP by activating a 400-Hz sensitive mechanism capable of integrating spatially separated granule cell inputs. This may reflect how LTP is normally produced in the dentate gyrus.
长时程增强（LTP）是突触效能的一种持久增强，被认为是学习和记忆的一种模型。在麻醉大鼠中，通过以100至400赫兹的频率刺激内侧或外侧穿通通路来激活齿状颗粒细胞，优先在400赫兹时产生受刺激通路的LTP。然而，海马体通路通常不会以这种高频率放电。然后分别以200赫兹的刺激施加于内侧或外侧通路，同时施加于两条通路，或以异步方式施加于两条通路，以使施加于颗粒细胞树突的复合刺激为400赫兹。LTP优先在异步条件下产生。因此，以较低频率、生理输入群以异步方式到达内侧和外侧突触时，可以通过激活一种能够整合空间上分离的颗粒细胞输入的400赫兹敏感机制来诱导LTP。这可能反映了齿状回中LTP通常是如何产生的。
