Almuraikhy Shamma, Anwardeen Najeha, Doudin Asmma, Sellami Maha, Domling Alexander, Agouni Abdelali, Althani Asmaa A, Elrayess Mohamed A
Biomedical Research Center, Qatar University, Doha P.O. Box 2713, Qatar.
Groningen Research Institute of Pharmacy, Drug Design, Groningen University, 9713 AV Groningen, The Netherlands.
Metabolites. 2023 Aug 27;13(9):973. doi: 10.3390/metabo13090973.
Physical activity (PA) is known to have beneficial effects on health, primarily through its antioxidative stress properties. However, the specific metabolic pathways that underlie these effects are not fully understood. This study aimed to investigate the metabolic pathways that are involved in the protective effects of moderate PA in non-obese and healthy individuals. Data on 305 young, non-obese participants were obtained from the Qatar Biobank. The participants were classified as active or sedentary based on their self-reported PA levels. Plasma metabolomics data were collected and analyzed to identify differences in metabolic pathways between the two groups. The results showed that active participants had increased activation of antioxidative, stress-related pathways, including lysoplasmalogen, plasmalogen, phosphatidylcholine, vitamin A, and glutathione. Additionally, there were significant associations between glutathione metabolites and certain clinical traits, including bilirubin, uric acid, hemoglobin, and iron. This study provides new insights into the metabolic pathways that are involved in the protective effects of moderate PA in non-obese and healthy individuals. The findings may have implications for the development of new therapeutic strategies that target these pathways.
众所周知，身体活动（PA）对健康有益，主要是通过其抗氧化应激特性。然而，这些作用背后的具体代谢途径尚未完全了解。本研究旨在调查中度PA对非肥胖健康个体产生保护作用所涉及的代谢途径。从卡塔尔生物银行获得了305名年轻非肥胖参与者的数据。根据参与者自我报告的PA水平将其分为活跃组或久坐组。收集并分析血浆代谢组学数据，以确定两组之间代谢途径的差异。结果表明，活跃参与者的抗氧化、应激相关途径的激活增加，包括溶血磷脂酰乙醇胺、缩醛磷脂、磷脂酰胆碱、维生素A和谷胱甘肽。此外，谷胱甘肽代谢物与某些临床特征之间存在显著关联，包括胆红素、尿酸、血红蛋白和铁。本研究为中度PA对非肥胖健康个体产生保护作用所涉及的代谢途径提供了新的见解。这些发现可能对针对这些途径的新治疗策略的开发具有启示意义。
