Department of Reproductive Medicine, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.
Department of Reproductive Medicine, Longhua Women and Children's Health Hospital, 68 Huawang Road, Shenzhen, China.
Arch Gynecol Obstet. 2024 Jan;309(1):287-293. doi: 10.1007/s00404-023-07212-4. Epub 2023 Sep 27.
The aim of this study was to investigate the efficacy and safety of early cumulus cell removal (ECCR) during human in vitro fertilization (IVF).
A retrospective analysis was performed between January 2011 and December 2019. The study enrolled 1131 couples who underwent IVF treatment with ECCR. After propensity score matching at a 1:1 ratio, 1131 couples who underwent overnight coincubation of gametes were selected. The main outcome measure was the cumulative live birth rate. Secondary outcome measures included the cumulative pregnancy rate, polyspermy rate, available embryo rate, miscarriage rate, malformation rate, time to live birth, and oocyte-to-baby rate.
There were no significant differences found between the two groups in the polyspermy rate, available embryo rate, miscarriage rate, time to live birth, oocyte-to-baby rate, and neonatal congenital anomalies rate. The results of the study showed that ECCR was associated with a significantly higher cumulative live birth rate and cumulative pregnancy rate, along with a significantly lower fertilization rate.
ECCR tended to confer increased cumulative live birth rate and had no negative effect on the neonatal malformation rate.
本研究旨在探讨人类体外受精（IVF）中早期卵丘细胞去除（ECCR）的疗效和安全性。
对 2011 年 1 月至 2019 年 12 月期间的患者进行回顾性分析。本研究共纳入 1131 对接受 ECCR 治疗的 IVF 夫妇。经过 1:1 比例的倾向评分匹配后，选择了 1131 对接受过夜共培养的夫妇。主要观察指标为累积活产率。次要观察指标包括累积妊娠率、多精率、可利用胚胎率、流产率、畸形率、活产时间和卵母细胞-婴儿率。
两组间多精率、可利用胚胎率、流产率、活产时间、卵母细胞-婴儿率和新生儿先天畸形率差异均无统计学意义。研究结果表明，ECCR 与累积活产率和累积妊娠率显著升高相关，而受精率显著降低。
ECCR 可能会提高累积活产率，且对新生儿畸形率没有负面影响。
