Osowski Adam, Fedoniuk Larysa, Bilyk Yaroslav, Fedchyshyn Olena, Sas Mykhailo, Kramar Solomiia, Lomakina Yuliia, Fik Volodymyr, Chorniy Sofija, Wojtkiewicz Joanna
Department of Pathophysiology, University of Warmia and Mazury in Olsztyn, 2 Oczapowskiego Street, 10-719 Olsztyn, Poland.
Histology and Embryology Department, I. Horbachevsky Ternopil National Medical University, 1 Maidan Voli Street, 46001 Ternopil, Ukraine.
Toxics. 2023 Sep 10;11(9):769. doi: 10.3390/toxics11090769.
Lead is known to be highly toxic to humans, causing various disorders infetal development. An experiment was conducted to examine the effects of lead acetate on the structural organization of female rat ovaries. The study involved 40 non-linear female rats divided into four groups: a control group, a low-dose group, a moderate-dose group, and a high-dose group. The rats were given lead acetate solutions in varying doses for 30 days, and their ovarian tissue was examined using light microscopy.The results showed that increasing doses of lead acetate led to morphological changes in the cortex and medulla of the rat ovaries. The changes were characterized by a decrease in ovarian mass, alterations in the thickness of the tunica albuginea (protein envelope), and a reduction in the number of follicles. Light microscopy revealed that exposure to lead acetate resulted in a significant decrease in the number of follicles in all experimental groups, with the high-dose group experiencing the most significant decrease.These findings suggest that lead acetate has a dose-dependent negative impact on the morphology and function of female rat ovaries. Further studies are needed to investigate the potential impact of lead on human ovarian tissue.
众所周知，铅对人体具有高毒性，会导致胎儿发育出现各种紊乱。进行了一项实验来研究醋酸铅对雌性大鼠卵巢结构组织的影响。该研究涉及40只未生育的雌性大鼠，分为四组：对照组、低剂量组、中剂量组和高剂量组。给大鼠给予不同剂量的醋酸铅溶液，持续30天，并用光学显微镜检查它们的卵巢组织。结果表明，醋酸铅剂量增加会导致大鼠卵巢皮质和髓质出现形态学变化。这些变化的特征是卵巢质量下降、白膜（蛋白质包膜）厚度改变以及卵泡数量减少。光学显微镜显示，所有实验组中，接触醋酸铅均导致卵泡数量显著减少，高剂量组减少最为显著。这些发现表明，醋酸铅对雌性大鼠卵巢的形态和功能具有剂量依赖性负面影响。需要进一步研究来调查铅对人类卵巢组织的潜在影响。
