Division of Emergency Medicine, Nemours Children's Hospital and Sidney Kimmel Medical College of Thomas Jefferson University, Wilmington, Delaware, USA.
Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania, USA.
J Pediatric Infect Dis Soc. 2023 Oct 28;12(10):553-555. doi: 10.1093/jpids/piad073.
In our prospective cohort of 192 children with a physician-diagnosed erythema migrans (EM) lesion, two-tier Lyme disease serology had higher sensitivity in children with multiple EM lesions (76.8% multiple lesions vs. 38.1% single EM; difference 38.7%, 95% confidence interval 24.8%-50.4%). The diagnosis of cutaneous Lyme disease should be based on careful physical examination rather than laboratory testing.
在我们前瞻性的 192 名经医生诊断患有游走性红斑（EM）病变的儿童队列中，双层莱姆病血清学检测在多发性 EM 病变的儿童中具有更高的敏感性（多发性病变 76.8% vs. 单发性 EM 38.1%；差异 38.7%，95%置信区间 24.8%-50.4%）。皮肤莱姆病的诊断应基于仔细的体格检查，而不是实验室检查。
