一种基于人类基因组编辑的MLL::AF4急性淋巴细胞白血病模型概括了关键的细胞和分子白血病发生特征。

A human genome editing-based MLL::AF4 ALL model recapitulates key cellular and molecular leukemogenic features.

作者信息

Bueno Clara, Torres-Ruiz Raul, Velasco-Hernandez Talia, Molina Oscar, Petazzi Paolo, Martinez Alba, Rodriguez Virginia, Vinyoles Meritxell, Cantilena Sandra, Williams Owen, Vega-Garcia Nerea, Rodriguez-Perales Sandra, Segovia Jose C, Quintana-Bustamante Oscar, Roy Anindita, Meyer Claus, Marschalek Rolf, Smith Alastair L, Milne Thomas A, Fraga Mario F, Tejedor Juan Ramón, Menéndez Pablo

机构信息

Stem Cell Biology, Immunotherapy and Developmental Leukemia Laboratory. Josep Carreras Leukemia Research Institute, Barcelona, Spain.

Spanish Network for Advanced Therapies, Carlos III Health Institute, Barcelona, Spain.

出版信息

Blood. 2023 Nov 16;142(20):1752-1756. doi: 10.1182/blood.2023020858.

DOI:10.1182/blood.2023020858

PMID:37756522

Abstract

Cellular ontogeny and MLL breakpoint site influence the capacity of MLL-edited CD34+ hematopoietic cells to initiate and recapitulate infant patients' features in pro-B-cell acute lymphoblastic leukemia (B-ALL). We provide key insights into the leukemogenic determinants of MLL-AF4+ infant B-ALL.

摘要

细胞个体发生和混合谱系白血病（MLL）断点位置影响MLL编辑的CD34+造血细胞在早前B细胞急性淋巴细胞白血病（B-ALL）中启动并重现婴儿患者特征的能力。我们对MLL-AF4+婴儿B-ALL的白血病发生决定因素提供了关键见解。