Yasoshima M, Masuda Y
Toxicol Lett. 1986 Sep;32(3):179-84. doi: 10.1016/0378-4274(86)90105-0.
Effect of carbon disulfide (CS2) on toxic action of 11 organophosphorus (OP) insecticides were examined by determining the plasma cholinesterase activity in mice. CS2 pretreatment potentiated the anticholinesterase action of parathion and EPN, but suppressed that of dimethoate and diazinon. CS2 had no significant effect or a slightly suppressive effect on the other compounds. Some of these effects were contrasted with the reported alteration of the toxicity following phenobarbital pretreatment. CS2 administration suppressed both detoxification and activation of parathion and EPN by liver microsomes in vitro, as measured by p-nitrophenol production and cholinesterase inhibition, respectively. Causal relationship between the in vitro and in vivo observations, however, remains to be clarified.
通过测定小鼠血浆胆碱酯酶活性，研究了二硫化碳（CS2）对11种有机磷（OP）杀虫剂毒性作用的影响。CS2预处理增强了对硫磷和EPN的抗胆碱酯酶作用，但抑制了乐果和二嗪农的抗胆碱酯酶作用。CS2对其他化合物无显著影响或有轻微抑制作用。其中一些作用与苯巴比妥预处理后报道的毒性改变形成对比。通过分别测定对硝基苯酚生成量和胆碱酯酶抑制率，发现CS2给药抑制了体外肝微粒体对对硫磷和EPN的解毒及活化作用。然而，体外和体内观察结果之间的因果关系仍有待阐明。
