Koizumi A, McCloud L, Imamura T
Toxicol Lett. 1986 Sep;32(3):185-94. doi: 10.1016/0378-4274(86)90106-2.
Pregnant rats (N = 7) were dosed p.o. with O,O,S-trimethyl phosphorothioate (OOS-TMP) (LD50 = 85) at 20 mg/kg on days G8 and G10. Seven animals were treated with corn oil and pair-fed. Five control animals were treated with corn oil. The abdomen was palpated on day G15 and in 4 animals out of 7 treated with OOS-TMP, complete resorption was observed. All pair-fed and control animals maintained pregnancy until day G21. Total number of resorption/number of implants was 60/95 (63.2%) in OOS-TMP animals, 21/82 (25.6%) in pair-fed animals and 4/65 (6.5%) in control animals. Incidence of complete resorption and % resorption were significantly higher (P less than 0.03 and P less than 0.01) in comparison with those in pair-fed animals. Fetuses from OOS-TMP mothers showed slight growth retardation. By skeletal examination, a missing vertebra and delayed ossifications were found in animals treated with OOS-TMP (20 mg/kg).
妊娠大鼠（N = 7）在妊娠第8天和第10天经口给予O,O,S - 三甲基硫代磷酸酯（OOS - TMP）（半数致死量= 85），剂量为20mg/kg。7只动物用玉米油处理并配对饲养。5只对照动物用玉米油处理。在妊娠第15天触诊腹部，在7只接受OOS - TMP处理的动物中有4只观察到完全吸收。所有配对饲养和对照动物维持妊娠至第21天。OOS - TMP处理的动物中吸收总数/着床数为60/95（63.2%），配对饲养动物中为21/82（25.6%），对照动物中为4/65（6.5%）。与配对饲养动物相比，完全吸收的发生率和吸收百分比显著更高（P < 0.03和P < 0.01）。OOS - TMP处理的母鼠所产胎儿显示出轻微生长迟缓。通过骨骼检查，在接受OOS - TMP（20mg/kg）处理的动物中发现有一个椎骨缺失和骨化延迟。
