Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
Social Determinants of Health Research Center, School of Nursing and Midwifery, Lorestan University of Medical Sciences, Khorramabad, 6814993165, Iran.
Explore (NY). 2024 May-Jun;20(3):362-370. doi: 10.1016/j.explore.2023.09.008. Epub 2023 Sep 21.
In patients living with chronic obstructive pulmonary disease (COPD), cognitive impairment and reduced activities of daily living (ADLs) are associated with poor clinical outcomes.
The aim of the present study was to determine the effect of rosemary hydroalcoholic extract on cognitive function and ADLs in patients with COPD.
A total of 77 COPD patients aged 40-80 years were assigned to two intervention and control groups by random stratified block method in the current tripleblind clinical trial. The intervention group received 500 mg rosemary capsules and the control group received oral capsules containing corn powder twice a day, one to two hours before breakfast and dinner, for two months. The Montreal Cognitive Assessment-Basic (MoCA-B), London Chest Activity of Daily Living scale (LCADL) and Lawton Instrumental Activities of Daily Living (IADL) were used to measure cognitive function and the measure of basic and instrumental daily life activities, before and after the intervention, respectively.
The mean total score of cognitive function (P = 0.022) and the two subscales of abstraction (P = 0.003) and naming (P = 0.034) significantly increased after the intervention in the intervention group. There was no significant difference between the intervention and control groups in terms of changes in the mean scores of IADL and LCADL (P < 0.05). The final statistical model showed that the changes in the total mean score of cognitive function (P = 0.014) and IADL (P = 0.047) in intervention group patients are significantly higher than in the control group after adjusting the effect of obstructive sleep apnea (OSA).
The rosemary hydroalcoholic extract can be effective in improving cognitive function and IADL in patients with COPD, but not LCADL.
IRCT20150919024080N16.
在患有慢性阻塞性肺疾病（COPD）的患者中，认知障碍和日常生活活动能力（ADLs）下降与不良临床结局相关。
本研究旨在确定迷迭香水醇提取物对 COPD 患者认知功能和 ADLs 的影响。
本研究采用随机分层区组方法，将 77 名年龄在 40-80 岁的 COPD 患者分为两组，干预组患者服用 500mg 迷迭香胶囊，对照组患者服用含玉米粉的口服胶囊，每日两次，早餐和晚餐前 1-2 小时服用，疗程为 2 个月。分别在干预前后使用蒙特利尔认知评估-基础量表（MoCA-B）、伦敦胸部日常生活活动量表（LCADL）和 Lawton 工具性日常生活活动量表（IADL）评估认知功能和日常生活活动的基本和工具性活动能力。
干预后，干预组患者的认知功能总分（P=0.022）和抽象（P=0.003）和命名（P=0.034）两个亚量表的总分均显著增加。干预组和对照组患者 IADL 和 LCADL 平均评分的变化差异无统计学意义（P<0.05）。最终的统计模型表明，调整阻塞性睡眠呼吸暂停（OSA）影响后，干预组患者认知功能总分（P=0.014）和 IADL （P=0.047）的变化显著高于对照组。
迷迭香水醇提取物可有效改善 COPD 患者的认知功能和 IADL，但对 LCADL 无影响。
IRCT20150919024080N16。
