Suppr超能文献

强直性脊柱炎患者低骨小梁评分的患病率及其与疾病严重程度和活动度的关系。

Prevalence of low trabecular bone score and its association with disease severity and activity in patients with axial spondyloarthritis.

机构信息

Rheumatic Diseases Unit, Department of Internal Medicine, Phramongkutklao Hospital and College of Medicine, 315 Ratchawithi Road, Ratchathewi District, Bangkok, 10400, Thailand.

Division of Rheumatology, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

出版信息

Sci Rep. 2023 Sep 27;13(1):16258. doi: 10.1038/s41598-023-43321-5.

Abstract

Axial spondyloarthritis (axSpA) increases the risk of osteoporosis and vertebral fractures. Bone mineral density (BMD) measured by dual X-ray absorptiometry (DXA) has limitations in axSpA patients. Trabecular bone score (TBS) indirectly assesses bone microarchitecture and can be used to predict fracture risk. However, few studies have investigated the role of TBS in axSpA patients. The objective of this study were to compare TBS between axSpA patients and 1:1 sex- and age-matched healthy volunteers and determine factors associated with low TBS in axSpA patients. A cross-sectional study was conducted in two tertiary-care hospitals. A total of 137 axSpA patients and healthy volunteers were enrolled. Demographics, disease characteristics, and risk factors for osteoporosis were recorded. TBS, BMD at the lumbar spine, hip, and vertebral fractures were assessed by DXA. Low TBS was defined as a TBS value < 1.230. Factors associated with low TBS were examined by logistic regression. Most patients were male (75.9%) and tested positive for HLA-B27 (88.3%). The mean (SD) age was 42.8 (12.0) years. The mean (SD) of TBS in the axSpA patients was lower than those in the healthy volunteers [1.402 (0.107) vs 1.440 (0.086), respectively; p = 0.002]. The mean (SD) of lumbar BMD in the axSpA patients was higher than in healthy volunteers [1.186 (0.212) vs 1.087 (0.124), p < 0.001], whereas the mean (SD) of femoral neck BMD in the axSpA group was lower than that in the healthy volunteers [0.867 (0.136) vs 0.904 (0.155), p = 0.038]. Disease severity as indicated by sacroiliac joint fusion and a high ASDAS score were associated with low TBS with the odds ratios (95% confidence interval) of 11.8 (1.2-115.4) and 5.2 (1.6-16.9), respectively. In conclusion, axSpA patients had a higher prevalence of low TBS than healthy volunteers. Sacroiliac joint fusion and a high ASDAS score were associated with low TBS.

摘要

中轴型脊柱关节炎(axSpA)会增加骨质疏松症和椎体骨折的风险。双能 X 线吸收法(DXA)测量的骨密度(BMD)在 axSpA 患者中有其局限性。骨小梁评分(TBS)间接评估骨微结构,可用于预测骨折风险。然而,很少有研究探讨 TBS 在 axSpA 患者中的作用。本研究旨在比较 axSpA 患者与 1:1 性别和年龄匹配的健康志愿者之间的 TBS,并确定 axSpA 患者中 TBS 降低的相关因素。这项横断面研究在两家三级保健医院进行。共纳入 137 例 axSpA 患者和健康志愿者。记录人口统计学、疾病特征和骨质疏松症危险因素。通过 DXA 评估腰椎、髋部和椎体的 TBS、BMD。低 TBS 定义为 TBS 值<1.230。使用逻辑回归检查与低 TBS 相关的因素。大多数患者为男性(75.9%),HLA-B27 阳性(88.3%)。axSpA 患者的平均(SD)年龄为 42.8(12.0)岁。axSpA 患者的 TBS 平均值(SD)低于健康志愿者[1.402(0.107)比 1.440(0.086),p=0.002]。axSpA 患者的腰椎 BMD 平均值(SD)高于健康志愿者[1.186(0.212)比 1.087(0.124),p<0.001],而 axSpA 组的股骨颈 BMD 平均值(SD)低于健康志愿者[0.867(0.136)比 0.904(0.155),p=0.038]。骶髂关节融合和较高的 ASDAS 评分表示疾病严重程度与低 TBS 相关,比值比(95%置信区间)分别为 11.8(1.2-115.4)和 5.2(1.6-16.9)。总之,axSpA 患者的低 TBS 发生率高于健康志愿者。骶髂关节融合和较高的 ASDAS 评分与低 TBS 相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a83c/10533482/9da1f847e66f/41598_2023_43321_Fig1_HTML.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验