[乙酰胆碱对肝线粒体中α-酮戊二酸氧化的激活作用]
[Acetylcholine activation of alpha-ketoglutarate oxidation in liver mitochondria].
作者信息
Shostakovskaia I V, Doliba N M, Gordiĭ S K, Babskiĭ A M, Kondrashova M N
出版信息
Ukr Biokhim Zh (1978). 1986 Sep-Oct;58(5):54-61.
Activation of alpha-ketoglutarate oxidation in the rat liver mitochondria takes place 15 and 30 min after intraperitoneal injection of acetyl choline. This mediator in doses of 25, 50 and 100 micrograms per 100 g of body weight causes a pronounced stimulation of phosphorylation respiration rate and calcium capacity of mitochondria with alpha-ketoglutarate oxidation. Acetyl choline is found to have a moderate inhibitory action on oxidation of lower (physiological) concentrations of succinate. Its stimulating action on alpha-ketoglutarate oxidation is associated with activation of M-cholinoreceptors; atropine, a choline-blocker, removes completely this effect. It is supposed that alpha-ketoglutarate and succinate are included into the composition of two reciprocal hormonal-substrate nucleotide systems.
大鼠肝脏线粒体中α-酮戊二酸氧化的激活发生在腹腔注射乙酰胆碱后15分钟和30分钟。每100克体重25、50和100微克剂量的这种介质会显著刺激线粒体的磷酸化呼吸速率以及α-酮戊二酸氧化的钙容量。发现乙酰胆碱对较低（生理）浓度的琥珀酸氧化有适度的抑制作用。其对α-酮戊二酸氧化的刺激作用与M胆碱受体的激活有关；胆碱阻断剂阿托品完全消除了这种作用。据推测，α-酮戊二酸和琥珀酸包含在两个相互的激素-底物核苷酸系统的组成中。
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