Silvers W K, Collins N H
Transplantation. 1979 Jul;28(1):57-9. doi: 10.1097/00007890-197907000-00013.
It has been well documented that virgin female rats previously systemically sensitized against H-Y antigen almost invariably reject male skin isografts of adult origin. However, when the donor is a neonatal animal, these H-Y-incompatible grafts are often permanently accepted. Furthermore, such neonatal male skin grafts are frequently able to induce a state of unresponsiveness to subsequent grafts of adult male skin. This ability to induce tolerance is evidently dependent upon the persistence of the neonatal skin graft as it does not occur if the neonatal graft is rejected. Thus, the behavior of H-Y-incompatible neonatal skin grafts in rats parallels their behavior in mice.
已有充分的文献记载，先前对H-Y抗原进行全身致敏的处女雌鼠几乎总是排斥成年来源的雄性皮肤同基因移植片。然而，当供体是新生动物时，这些H-Y不相容的移植片常常被永久接受。此外，这种新生雄性皮肤移植片常常能够诱导对成年雄性皮肤后续移植片的无反应状态。这种诱导耐受的能力显然取决于新生皮肤移植片的持续存在，因为如果新生移植片被排斥，这种情况就不会发生。因此，H-Y不相容的新生皮肤移植片在大鼠中的行为与其在小鼠中的行为相似。
