Takata Kohei, Imaizumi Satoshi, Iwata Atsushi, Zhang Bo, Kawachi Emi, Miura Shin-Ichiro, Ogawa Masahiro
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka 814-0180, Japan.
Department of Clinical Laboratory and Transfusion, Fukuoka University Hospital, Fukuoka 814-0180, Japan.
Biomolecules. 2023 Aug 22;13(9):1278. doi: 10.3390/biom13091278.
High-density lipoprotein (HDL) functionality has been reported to be associated with coronary artery disease (CAD). However, little is known about the impact of HDL functionality on coronary atherosclerosis. Thirty-eight type 2 diabetic patients with CAD who underwent percutaneous coronary intervention were examined. Coronary atheroma burden and plaque composition of the culprit lesions were assessed using conventional gray-scale and integrated backscatter intravascular ultrasound. HDL-mediated cholesterol efflux capacity (HDL-CEC) and HDL antioxidant capacity, estimated as HDL inflammatory index (HII), were examined. The associations between HDL functionality and coronary plaques were analyzed using multivariate data analysis, including principal components analysis and orthogonal partial least squares (OPLS) models. Percent atheroma volume was correlated with HDL-CEC (r = 0.34, = 0.04) but not with HII ( = 0.65). The OPLS model demonstrated that the percentage lipid volume was significantly associated with HDL functionality [coefficient (95% confidence interval); HDL-CEC: -0.26 (-0.49, -0.04); HII: 0.34 (0.08, 2.60), respectively]. HII exhibited the highest variable importance in projection score, indicating the greatest contribution. HDL functionality was associated with coronary plaque composition, a key component of plaque vulnerability. Our findings highlight the potential importance of HDL functionality for coronary plaque stabilization.
据报道，高密度脂蛋白（HDL）功能与冠状动脉疾病（CAD）有关。然而，关于HDL功能对冠状动脉粥样硬化的影响却知之甚少。对38例接受经皮冠状动脉介入治疗的2型糖尿病CAD患者进行了检查。使用传统的灰阶和背向散射积分血管内超声评估罪犯病变的冠状动脉粥样斑块负荷和斑块成分。检测了HDL介导的胆固醇流出能力（HDL-CEC）和HDL抗氧化能力，以HDL炎症指数（HII）估算。使用多变量数据分析，包括主成分分析和正交偏最小二乘法（OPLS）模型，分析HDL功能与冠状动脉斑块之间的关联。粥样斑块体积百分比与HDL-CEC相关（r = 0.34，P = 0.04），但与HII无关（P = 0.65）。OPLS模型表明，脂质体积百分比与HDL功能显著相关[系数（95%置信区间）；HDL-CEC：-0.26（-0.49，-0.04）；HII：0.34（0.08，2.60）]。HII在投影得分中表现出最高的变量重要性，表明其贡献最大。HDL功能与冠状动脉斑块成分有关，而斑块成分是斑块易损性的关键组成部分。我们的研究结果突出了HDL功能对冠状动脉斑块稳定的潜在重要性。
