Zhang Chong, Wang Guanhuier, An Yang
Department of Plastic Surgery, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100191, China.
Biomolecules. 2023 Aug 25;13(9):1302. doi: 10.3390/biom13091302.
The nasal septal cartilage plays an important role in preventing the collapse of the nasal bones and maintaining the appearance of the nose. In the context of inherent difficulties regarding septal cartilage repair and the shortage of cartilage graft resources for regeneration, tissue engineering, especially the in situ strategy based on scaffolds, has become a new prospect and become one of the most promising approaches. Given that it is difficult for chondrocytes to achieve directional migration and secrete matrix components to participate in tissue repair after cartilage injury, cartilage progenitor cells (CPCs), with great migratory ability and stem cell characteristics, have caught the attention of researchers and brought hope for nasal septal cartilage in situ regeneration. In this review, we first summarized the distribution, characteristics, isolation, and culture methods of nasal septal CPCs. Subsequently, we described the roles of migratory CPCs in cartilage regeneration. Finally, we reviewed the existing studies on CPCs-based cartilage tissue engineering and summarized the strategies for promoting the migration and chondrogenesis of CPCs so as to provide ideas for achieving nasal septal cartilage in situ regeneration.
鼻中隔软骨在防止鼻骨塌陷和维持鼻外形方面发挥着重要作用。鉴于鼻中隔软骨修复存在固有困难以及用于再生的软骨移植资源短缺，组织工程，尤其是基于支架的原位策略，已成为一种新的前景并成为最有前途的方法之一。由于软骨细胞在软骨损伤后难以实现定向迁移并分泌基质成分参与组织修复，具有强大迁移能力和干细胞特性的软骨祖细胞（CPCs）引起了研究人员的关注，并为鼻中隔软骨原位再生带来了希望。在这篇综述中，我们首先总结了鼻中隔CPCs的分布、特征、分离和培养方法。随后，我们描述了迁移性CPCs在软骨再生中的作用。最后，我们回顾了基于CPCs的软骨组织工程的现有研究，并总结了促进CPCs迁移和软骨形成的策略，以便为实现鼻中隔软骨原位再生提供思路。
