Stafford Owen, Gleeson Christina, Egan Ciara, Tunney Conall, Rooney Brendan, O'Keeffe Fiadhnait, McDermott Garret, Baron-Cohen Simon, Burke Tom
School of Psychology, University College Dublin, D04 F6X4 Dublin, Ireland.
School of Psychology, University of Galway, H91 TK33 Galway, Ireland.
Brain Sci. 2023 Aug 31;13(9):1268. doi: 10.3390/brainsci13091268.
Social cognition has a broad theoretical definition, which includes the ability to mentalise, i.e., recognise and infer mental states to explain and predict another's behaviour. There is growing recognition of the clinical, diagnostic, and prognostic value of assessing a person's ability to perform social cognitive tasks, particularly aspects of theory of mind, such as mentalising. One such measure of mentalising is the 'Reading the Mind in the Eyes' test (RMET). This systematic review and meta-analysis consider performance on the RMET, applied to people with neurodegenerative conditions in matched control studies, since its publication in 2001. Overall, this review includes 22 papers with data from N = 800 participants with neurodegenerative conditions: Alzheimer's disease, = 31; Parkinson's disease, = 221; Lewy body dementia, = 33; motor neuron disease, = 218; Huntington's disease = 80; multiple sclerosis, = 217; and N = 601 matched typical controls. Our meta-analyses show that deficits in mentalising, as measured by the RMET, are consistently reported across neurodegenerative conditions, with participants in both early and late disease stages being affected. Social cognition is an emerging field of cognitive neuroscience requiring specific and sensitive measurement across each subdomain. Adult-based meta-normative data feature, for which future groups or individuals could be compared against, and hypotheses relating to the source of these mentalising deficits are further discussed. This review was registered with PROSPERO (CRD42020182874).
社会认知有一个宽泛的理论定义，其中包括心理化能力，即识别和推断心理状态以解释和预测他人行为的能力。人们越来越认识到评估一个人执行社会认知任务的能力，特别是心理理论的各个方面，如心理化的临床、诊断和预后价值。心理化的一种测量方法是“读心术”测试（RMET）。本系统综述和荟萃分析考虑了自2001年发表以来，RMET在匹配对照研究中应用于神经退行性疾病患者的表现。总体而言，本综述包括22篇论文，数据来自N = 800名神经退行性疾病患者：阿尔茨海默病，N = 31；帕金森病，N = 221；路易体痴呆，N = 33；运动神经元病，N = 218；亨廷顿舞蹈病，N = 80；多发性硬化症，N = 217；以及N = 601名匹配的典型对照。我们的荟萃分析表明，在各种神经退行性疾病中，RMET测量的心理化缺陷均有一致报道，疾病早期和晚期的参与者均受影响。社会认知是认知神经科学的一个新兴领域，需要对每个子领域进行特定且敏感的测量。文中还介绍了基于成人的元规范数据特征，未来的群体或个体可与之进行比较，并进一步讨论了与这些心理化缺陷来源相关的假设。本综述已在国际前瞻性系统评价注册库（PROSPERO，注册号：CRD42020182874）登记。
