Gębarowski Tomasz, Wiatrak Benita, Jęśkowiak-Kossakowska Izabela, Grajzer Magdalena, Prescha Anna
Department of Biostructure and Animal Physiology, The Wroclaw University of Environmental and Life Sciences, Kożuchowska 1/3, 51-631 Wroclaw, Poland.
Department of Pharmacology, Faculty of Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 2, 50-345 Wroclaw, Poland.
Biomedicines. 2023 Sep 21;11(9):2592. doi: 10.3390/biomedicines11092592.
Colorectal cancer is a major global health concern, and the need for effective chemopreventive agents is paramount. This study aimed to evaluate the potential of oils from transgenically modified flax for the prevention of colorectal cancer, in relation to the oil concertation. Flaxseed oils were obtained from traditional (Nike) and genetically modified flax lines (M and B). Cell viability assays were performed on various cancer cell lines, including colon adenocarcinoma cells. Flaxseed oil B exhibited the strongest anti-proliferative properties compared to the reference drugs and other oils. Additionally, M and B oils showed enhanced accumulation of Rhodamine 123 and increased apoptosis in colorectal cancer cells. M oil exhibited the highest levels of p53 protein. Notably, the tested transgenic oils did not induce metastasis and displayed stronger inhibition of COX-1 compared to COX-2. These data indicate the utility of flaxseed oils, especially from the M line, as adjuvants in colorectal cancer treatment, targeting the colon specifically.
结直肠癌是一个重大的全球健康问题，因此对有效的化学预防剂的需求至关重要。本研究旨在评估转基因亚麻油在预防结直肠癌方面的潜力，并研究其与油浓度的关系。亚麻籽油取自传统（耐克）和转基因亚麻品系（M和B）。对包括结肠腺癌细胞在内的多种癌细胞系进行了细胞活力测定。与参考药物和其他油相比，亚麻籽油B表现出最强的抗增殖特性。此外，M油和B油显示出若丹明123在结直肠癌细胞中的积累增加以及细胞凋亡增加。M油中p53蛋白水平最高。值得注意的是，所测试的转基因油不会诱导转移，并且与COX-2相比，对COX-1的抑制作用更强。这些数据表明亚麻籽油，特别是M品系的亚麻籽油，作为结直肠癌治疗的佐剂具有实用性，尤其对结肠具有特异性靶向作用。
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