Rodríguez-García Carmen, Gutiérrez-Santiago Francisco
Department of Health Sciences, Faculty of Experimental Sciences, University of Jaen, Campus las Lagunillas s/n, 23071 Jaen, Spain.
University Institute of Research in Olive Groves and Olive Oils, University of Jaen, Campus las Lagunillas s/n, 23071 Jaen, Spain.
Life (Basel). 2023 Jan 18;13(2):264. doi: 10.3390/life13020264.
Colorectal cancer (CRC) is one of the most common cancers worldwide. Its main modifiable risk factors are diet, alcohol consumption, and smoking. Thus, the right approach through lifestyle changes may lead to its prevention. In fact, some natural dietary components have exhibited chemopreventive activity through modulation of cellular processes involved in CRC development. Although cancer is a multi-factorial process, the study of post-translational modifications (PTMs) of proteins associated with CRC has recently gained interest, as inappropriate modification is closely related to the activation of cell signalling pathways involved in carcinogenesis. Therefore, this review aimed to collect the main PTMs associated with CRC, analyse the relationship between different proteins that are susceptible to inappropriate PTMs, and review the available scientific literature on the role of plant-based dietary compounds in modulating CRC-associated PTMs. In summary, this review suggested that some plant-based dietary components such as phenols, flavonoids, lignans, terpenoids, and alkaloids may be able to correct the inappropriate PTMs associated with CRC and promote apoptosis in tumour cells.
结直肠癌（CRC）是全球最常见的癌症之一。其主要的可改变风险因素包括饮食、饮酒和吸烟。因此，通过改变生活方式的正确方法可能会预防结直肠癌。事实上，一些天然饮食成分已通过调节参与结直肠癌发展的细胞过程表现出化学预防活性。尽管癌症是一个多因素过程，但最近对与结直肠癌相关的蛋白质的翻译后修饰（PTM）的研究引起了关注，因为不适当的修饰与参与致癌作用的细胞信号通路的激活密切相关。因此，本综述旨在收集与结直肠癌相关的主要PTM，分析易受不适当PTM影响的不同蛋白质之间的关系，并综述关于植物性膳食化合物在调节与结直肠癌相关的PTM中的作用的现有科学文献。总之，本综述表明，一些植物性膳食成分，如酚类、黄酮类、木脂素类、萜类和生物碱类，可能能够纠正与结直肠癌相关的不适当PTM，并促进肿瘤细胞凋亡。
