Zurashvili B Sh
Vopr Med Khim. 1986 Sep-Oct;32(5):53-6.
Content of thiamin and metabolism of ascorbic acid were studied in 150 male rats administered with ascorutin (vitamins C and P complex) after physical exercises within 10, 15 and 20 days. Content of the vitamins studied was decreased depending on duration and severity of the physical exercises. High doses of ascorutin simultaneously with physical exercises normalized the ascorbic acid content in adrenal glands and increased the vitamin concentration in blood. At the same time, ascorutin caused different decrease in content of thiamin in blood and liver tissue accompanied by a marked decrease of the transketolase activity in blood and by an increase in the TDP-effect. The data obtained suggest that ascorutin should be combined with compensatory doses of thiamin.
在150只雄性大鼠进行10天、15天和20天体育锻炼后，给予它们维生素C和芦丁复合物（抗坏血酸），对硫胺素含量和抗坏血酸代谢进行了研究。所研究的维生素含量根据体育锻炼的持续时间和强度而降低。高剂量的维生素C和芦丁复合物与体育锻炼同时进行，可使肾上腺中的抗坏血酸含量正常化，并增加血液中的维生素浓度。与此同时，维生素C和芦丁复合物导致血液和肝组织中硫胺素含量不同程度降低，同时血液中转酮醇酶活性显著降低，TDP效应增加。所得数据表明，维生素C和芦丁复合物应与硫胺素的补充剂量联合使用。
