膀胱炎与尤蒂普罗 Plus：真实世界证据
Cystitis and Utipro Plus: Real-World Evidence.
作者信息
Kostev Karel, Cai Tommaso
机构信息
Epidemiology, IQVIA S.L., 60549 Frankfurt am Main, Germany.
Department of Gynecology and Obstetrics, University Hospital Marburg, Philipps-University Marburg, 35043 Marburg, Germany.
出版信息
Healthcare (Basel). 2023 Sep 16;11(18):2564. doi: 10.3390/healthcare11182564.
BACKGROUND
The emergence of drug resistance in the etiological agents of uncomplicated urinary tract infections (UTIs) emphasizes the need to shift the paradigm towards alternative therapeutic strategies. The objective of the present study was to evaluate the use of a medical device containing xyloglucan, hibiscus, and propolis for reducing UTI symptomatic episodes, antibiotic prescription, and days of sick leave.
MATERIALS AND METHODS
It used retrospective, cross-sectional study data provided by office-based physicians from Germany (Disease Analyzer, IQVIA database), including those on 3586 patients with a diagnosis of UTI treated with Utipro Plus (Noventure, Barcelona, Spain) from January 2015 to December 2020.
RESULTS
The majority of patients were women (94.2%) and had a mean age (standard deviation, SD) of 57.7 years (19.0). Within 12 months after the prescription and compared to the 12 months before, it was observed that there was a reduction in the proportion of patients with at least one UTI diagnosis (from 79.4% to 36.4%, < 0.001), in antibiotic prescriptions (from 33.5% to 22.1%, < 0.001), and in the proportion of patients with at least one day of sick leave (from 4.1% to 2.7%).
CONCLUSIONS
The use of Utipro Plus is able to decrease UTI recurrence and can lead to the reduction of antibiotic prescriptions and disease burden in individuals affected by uncomplicated cystitis.
背景
单纯性尿路感染（UTI）病原体中耐药性的出现凸显了将治疗模式转向替代治疗策略的必要性。本研究的目的是评估一种含有木葡聚糖、芙蓉和蜂胶的医疗器械在减少UTI症状发作、抗生素处方和病假天数方面的作用。
材料与方法
本研究使用了德国基层医生提供的回顾性横断面研究数据（疾病分析器，IQVIA数据库），包括2015年1月至2020年12月期间3586例诊断为UTI并使用Utipro Plus（西班牙巴塞罗那Noventure公司）治疗的患者的数据。
结果
大多数患者为女性（94.2%），平均年龄（标准差，SD）为57.7岁（19.0）。在处方后的12个月内，与之前的12个月相比，观察到至少有一次UTI诊断的患者比例（从79.4%降至36.4%，<0.001）、抗生素处方（从33.5%降至22.1%，<0.001）以及至少有一天病假的患者比例（从4.1%降至2.7%）均有所下降。
结论
使用Utipro Plus能够减少UTI复发，并可降低单纯性膀胱炎患者的抗生素处方和疾病负担。
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