Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.
Genes (Basel). 2023 Aug 24;14(9):1675. doi: 10.3390/genes14091675.
has been a premier model organism for over a century and many discoveries in flies have furthered our understanding of human disease. Flies have been successfully applied to many aspects of health-based research spanning from behavioural addiction, to dysplasia, to RNA dysregulation and protein misfolding. Recently, tissues have been used to study biomolecular condensates and their role in multicellular systems. Identified in a wide range of plant and animal species, biomolecular condensates are dynamic, non-membrane-bound sub-compartments that have been observed and characterised in the cytoplasm and nuclei of many cell types. Condensate biology has exciting research prospects because of their diverse roles within cells, links to disease, and potential for therapeutics. In this review, we will discuss processing bodies (P bodies), a conserved biomolecular condensate, with a particular interest in how can be applied to advance our understanding of condensate biogenesis and their role in disease.
一个多世纪以来，果蝇一直是一种主要的模式生物，许多在果蝇身上的发现进一步加深了我们对人类疾病的理解。果蝇已被成功应用于许多以健康为基础的研究领域，从行为成瘾到发育不良，再到 RNA 失调和蛋白质错误折叠。最近， 组织已被用于研究生物分子凝聚物及其在多细胞系统中的作用。生物分子凝聚物在广泛的植物和动物物种中被发现，是动态的、非膜结合的亚区室，在许多细胞类型的细胞质和核中都有观察到和描述。由于其在细胞内的多种作用、与疾病的联系以及治疗的潜力，凝聚物生物学具有令人兴奋的研究前景。在这篇综述中，我们将讨论处理体 (P 体)，一种保守的生物分子凝聚物，特别关注 如何应用于推进我们对凝聚物生物发生及其在疾病中的作用的理解。
