与肥胖和代谢综合征相关的基因多态性与墨西哥成年人的关联。
Association of and Allelic Variants with Obesity and Metabolic Syndrome in Mexican Adults.
机构信息
School of Medicine, Autonomous University of Sinaloa, Culiacan Sinaloa 80019, Mexico.
Pediatric Hospital of Sinaloa, Constitución 530, Jorge Almada, Culiacan Sinaloa 80200, Mexico.
出版信息
Genes (Basel). 2023 Sep 8;14(9):1775. doi: 10.3390/genes14091775.
UNLABELLED
Metabolic diseases, including obesity, diabetes, and metabolic syndrome, are among the most important public health challenges worldwide. Metabolic diseases are classified as multifactorial diseases in which genetic variants such as single-nucleotide polymorphisms (SNPs) may play an important role. The present study aimed to identify associations linking allelic variants of the , , , , , and genes with anthropometric and biochemical traits and metabolic diseases (obesity or metabolic syndrome) in an adult population from northwestern Mexico.
METHODS
Blood samples were collected from 523 subjects, including 247 with normal weight, 276 with obesity, and 147 with metabolic syndrome. Anthropometric and biochemical characteristics were recorded, and single-nucleotide polymorphisms (SNPs) were genotyped by real-time PCR.
RESULTS
was significantly ( < 0.05) associated with BMI, weight, and waist-to-hip ratio; TMEM18 was significantly associated with systolic blood pressure and triglyceride levels; was significantly associated with HDL cholesterol levels. In addition, was associated with obesity ( = 1.0 × 10) and metabolic syndrome ( = 3.0 × 10), whereas was associated with obesity ( = 0.044).
CONCLUSIONS
The associations found in this study, mainly between allelic variants of and metabolic traits, obesity, and metabolic syndrome, may represent a risk for developing metabolic diseases in adult subjects from northwestern Mexico.
目的
本研究旨在鉴定与墨西哥西北部成人人群的人体测量学和生化特征及代谢疾病（肥胖或代谢综合征）相关的等位基因变异与 、 、 、 、 和 基因之间的关联。
方法
采集了 523 例受试者的血样，其中包括 247 例体重正常者、276 例肥胖者和 147 例代谢综合征患者。记录了人体测量学和生化特征，并通过实时 PCR 对单核苷酸多态性（SNP）进行了基因分型。
结果
（rs1020748）与 BMI、体重和腰臀比显著相关（ < 0.05）；TMEM18 与收缩压和甘油三酯水平显著相关； 与高密度脂蛋白胆固醇水平显著相关。此外， 与肥胖（ = 1.0 × 10）和代谢综合征（ = 3.0 × 10）相关，而 与肥胖（ = 0.044）相关。
结论
本研究主要发现了等位基因变异与代谢特征、肥胖和代谢综合征之间的关联，这些关联可能代表了墨西哥西北部成人发生代谢疾病的风险因素。
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