rs1801282 多态性的 G 等位基因使 PPARγ 基因易患肥胖和高胆固醇血症，而 rs3856806 多态性的 T 等位基因对血脂异常具有保护作用：系统评价和荟萃分析。
G Allele of the rs1801282 Polymorphism in PPARγ Gene Confers an Increased Risk of Obesity and Hypercholesterolemia, While T Allele of the rs3856806 Polymorphism Displays a Protective Role Against Dyslipidemia: A Systematic Review and Meta-Analysis.
机构信息
Central Laboratory, Clinical Medical College and Affiliated Hospital of Chengdu University, Chengdu, China.
Department of Cardiology, Clinical Medical College and Affiliated Hospital of Chengdu University, Chengdu, China.
出版信息
Front Endocrinol (Lausanne). 2022 Jun 29;13:919087. doi: 10.3389/fendo.2022.919087. eCollection 2022.
BACKGROUND
The relationships between the rs1801282 and rs3856806 polymorphisms in nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) gene and obesity indexes as well as serum lipid levels have been extensively investigated in various studies, but the results were inconsistent and even contradictory.
METHODS
PubMed, Google Scholar, Embase, Cochrane Library, Web of Science, Wanfang, CNKI and VIP databases were searched for eligible studies. The random-effTPDEects model was used, and standardized mean difference (SMD) with 95% confidence interval (CI) was calculated to estimate the differences in obesity indexes and serum lipid levels between the subjects with different genotypes in a dominant model. Heterogeneity among studies was assessed by Cochran's x-based Q-statistic test. Publication bias was identified by using Begg's test.
RESULTS
One hundred and twenty studies (70,317 subjects) and 33 studies (18,353 subjects) were identified in the analyses for the rs1801282 and rs3856806 polymorphisms, respectively. The G allele carriers of the rs1801282 polymorphism had higher levels of body mass index (SMD = 0.08 kg/m, 95% CI = 0.04 to 0.12 kg/m, < 0.001), waist circumference (SMD = 0.12 cm, 95% CI = 0.06 to 0.18 cm, < 0.001) and total cholesterol (SMD = 0.07 mmol/L, 95% CI = 0.02 to 0.11 mmol/L, < 0.01) than the CC homozygotes. The T allele carriers of the rs3856806 polymorphism had lower levels of low-density lipoprotein cholesterol (SMD = -0.09 mmol/L, 95% CI = -0.15 to -0.03 mmol/L, < 0.01) and higher levels of high-density lipoprotein cholesterol (SMD = 0.06 mmol/L, 95% CI = 0.02 to 0.10 mmol/L, < 0.01) than the CC homozygotes.
CONCLUSIONS
The meta-analysis suggests that the G allele of the rs1801282 polymorphism confers an increased risk of obesity and hypercholesterolemia, while the T allele of the rs3856806 polymorphism displays a protective role against dyslipidemia, which can partly explain the associations between these polymorphisms and cardiovascular disease.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/prospero/, identifier [CRD42022319347].
背景
核受体过氧化物酶体增殖物激活受体 γ（PPARγ）基因 rs1801282 和 rs3856806 多态性与肥胖指数和血清脂质水平之间的关系在许多研究中得到了广泛研究，但结果不一致，甚至相互矛盾。
方法
检索PubMed、Google Scholar、Embase、Cochrane Library、Web of Science、万方、CNKI 和 VIP 数据库，以获取合格的研究。采用随机效应 tPDEEfTs 模型，以标准化均数差（SMD）和 95%置信区间（CI）来估计显性模型中不同基因型个体的肥胖指数和血清脂质水平的差异。采用 Cochran's x 基于 Q 统计量检验评估研究间的异质性。采用 Begg's 检验识别发表偏倚。
结果
分别对 rs1801282 和 rs3856806 多态性进行分析，共纳入 120 项研究（70317 例）和 33 项研究（18353 例）。rs1801282 多态性的 G 等位基因携带者的体重指数（SMD=0.08kg/m，95%CI=0.04 至 0.12kg/m，<0.001）、腰围（SMD=0.12cm，95%CI=0.06 至 0.18cm，<0.001）和总胆固醇（SMD=0.07mmol/L，95%CI=0.02 至 0.11mmol/L，<0.01）水平较高，而 CC 纯合子较低。rs3856806 多态性的 T 等位基因携带者的低密度脂蛋白胆固醇（SMD=-0.09mmol/L，95%CI=-0.15 至-0.03mmol/L，<0.01）水平较低，高密度脂蛋白胆固醇（SMD=0.06mmol/L，95%CI=0.02 至 0.10mmol/L，<0.01）水平较高，而 CC 纯合子较低。
结论
荟萃分析表明，rs1801282 多态性的 G 等位基因增加肥胖和高胆固醇血症的风险，而 rs3856806 多态性的 T 等位基因对血脂异常具有保护作用，这可以部分解释这些多态性与心血管疾病之间的关联。
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