• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在寻找肺动脉高压的生物标志物时，细胞因子 IL-2、IL-4、IL-6、IL-10 和 IFN-γ 是否是合适的指标？

In the Search for Biomarkers of Pulmonary Arterial Hypertension, Are Cytokines IL-2, IL-4, IL-6, IL-10, and IFN-Gamma the Right Indicators to Use?

机构信息

Department of Cardiology, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, Poland.

Department of Experimental Immunology, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland.

出版信息

Int J Mol Sci. 2023 Sep 5;24(18):13694. doi: 10.3390/ijms241813694.

DOI:10.3390/ijms241813694
PMID:37761997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10530884/
Abstract

Pulmonary arterial hypertension (PAH) is a complex disorder characterized by increased pressure in the pulmonary arteries, leading to right heart failure. While the exact mechanisms underlying PAH are not fully understood, cytokines have been implicated in the pathogenesis of the disease. Cytokines play a crucial role in regulating immune responses and inflammation. These small proteins also play a key role in shaping the immunophenotype, which refers to the specific characteristics and functional properties of immune cells, which can have a significant impact on the development of PAH. The aim of this study was to determine the immunophenotype and the concentration of selected cytokines, IL-2, IL-4, IL-6, IL-10, and IFN-gamma, in patients diagnosed with PAH (with particular emphasis on subtypes) in relation to healthy volunteers. Based on the obtained results, we can conclude that in patients with PAH, the functioning of the immune system is deregulated as a result of a decrease in the percentage of selected subpopulations of immune cells in peripheral blood and changes in the concentration of tested cytokines in relation to healthy volunteers. In addition, a detailed analysis showed that there are statistically significant differences between the PAH subtypes and the tested immunological parameters. This may indicate a significant role of the immune system in the pathogenesis of PAH.

摘要

肺动脉高压（PAH）是一种复杂的疾病，其特征是肺动脉内压力升高，导致右心衰竭。虽然 PAH 的具体发病机制尚不完全清楚，但细胞因子已被认为与该疾病的发病机制有关。细胞因子在调节免疫反应和炎症中起着至关重要的作用。这些小分子蛋白在塑造免疫表型方面也起着关键作用，免疫表型是指免疫细胞的特定特征和功能特性，它对 PAH 的发展有重大影响。本研究的目的是确定诊断为 PAH（特别强调亚型）的患者与健康志愿者相比，其免疫表型和选定细胞因子（IL-2、IL-4、IL-6、IL-10 和 IFN-γ）的浓度。根据获得的结果，我们可以得出结论，在 PAH 患者中，由于外周血中选定免疫细胞亚群的百分比下降以及与健康志愿者相比测试细胞因子的浓度发生变化，免疫系统的功能失调。此外，详细分析表明，PAH 亚型与测试免疫参数之间存在统计学上的显著差异。这可能表明免疫系统在 PAH 的发病机制中起着重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e62/10530884/d62dab611bfd/ijms-24-13694-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e62/10530884/eb411fba4820/ijms-24-13694-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e62/10530884/df211b7b6c25/ijms-24-13694-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e62/10530884/7fee14c3bff3/ijms-24-13694-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e62/10530884/29679280a9ed/ijms-24-13694-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e62/10530884/017cbf13b04d/ijms-24-13694-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e62/10530884/f79106065751/ijms-24-13694-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e62/10530884/40a78c249969/ijms-24-13694-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e62/10530884/4ce59bc4085f/ijms-24-13694-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e62/10530884/e5d217b89610/ijms-24-13694-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e62/10530884/d62dab611bfd/ijms-24-13694-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e62/10530884/eb411fba4820/ijms-24-13694-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e62/10530884/df211b7b6c25/ijms-24-13694-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e62/10530884/7fee14c3bff3/ijms-24-13694-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e62/10530884/29679280a9ed/ijms-24-13694-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e62/10530884/017cbf13b04d/ijms-24-13694-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e62/10530884/f79106065751/ijms-24-13694-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e62/10530884/40a78c249969/ijms-24-13694-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e62/10530884/4ce59bc4085f/ijms-24-13694-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e62/10530884/e5d217b89610/ijms-24-13694-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e62/10530884/d62dab611bfd/ijms-24-13694-g010.jpg

相似文献

1
In the Search for Biomarkers of Pulmonary Arterial Hypertension, Are Cytokines IL-2, IL-4, IL-6, IL-10, and IFN-Gamma the Right Indicators to Use?在寻找肺动脉高压的生物标志物时，细胞因子 IL-2、IL-4、IL-6、IL-10 和 IFN-γ 是否是合适的指标？
Int J Mol Sci. 2023 Sep 5;24(18):13694. doi: 10.3390/ijms241813694.
2
Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages.Regnase-1 通过降解肺泡巨噬细胞中的白细胞介素-6 和血小板衍生生长因子预防肺动脉高压。
Circulation. 2022 Sep 27;146(13):1006-1022. doi: 10.1161/CIRCULATIONAHA.122.059435. Epub 2022 Aug 23.
3
Circulating markers of inflammation and angiogenesis and clinical outcomes across subtypes of pulmonary arterial hypertension.循环炎症和血管生成标志物与肺动脉高压各亚型的临床结局。
J Heart Lung Transplant. 2023 Feb;42(2):173-182. doi: 10.1016/j.healun.2022.10.026. Epub 2022 Nov 7.
4
Platelet-leukocyte aggregate formation and inflammation in patients with pulmonary arterial hypertension and CTEPH.血小板-白细胞聚集体形成与炎症在肺动脉高压和 CTEPH 患者中的作用。
Platelets. 2022 Nov 17;33(8):1199-1207. doi: 10.1080/09537104.2022.2087867. Epub 2022 Jun 14.
5
Evidence for the involvement of type I interferon in pulmonary arterial hypertension.Ⅰ型干扰素参与肺动脉高压的证据。
Circ Res. 2014 Feb 14;114(4):677-88. doi: 10.1161/CIRCRESAHA.114.302221. Epub 2013 Dec 13.
6
Inhibiting IL-6 in medicine: a new twist to sustain inhibition of his cytokine tin the therapy of Pulmonary Arterial Hypertension.医学中的白介素-6 抑制：维持细胞因子抑制的新策略在肺动脉高压治疗中的应用。
Pharmacol Res. 2023 Jun;192:106750. doi: 10.1016/j.phrs.2023.106750. Epub 2023 Mar 31.
7
Plasma markers in pulmonary hypertension subgroups correlate with patient survival.肺高血压亚组中的血浆标志物与患者生存率相关。
Respir Res. 2021 May 4;22(1):137. doi: 10.1186/s12931-021-01716-w.
8
Role of macrophages in pulmonary arterial hypertension.巨噬细胞在肺动脉高压中的作用。
Front Immunol. 2023 Apr 19;14:1152881. doi: 10.3389/fimmu.2023.1152881. eCollection 2023.
9
Interferon and alternative activation of monocyte/macrophages in systemic sclerosis-associated pulmonary arterial hypertension.干扰素与系统性硬化症相关肺动脉高压中单核细胞/巨噬细胞的替代性活化
Arthritis Rheum. 2011 Jun;63(6):1718-28. doi: 10.1002/art.30318.
10
CTLA-4 Expression Is a Promising Biomarker of Idiopathic Pulmonary Arterial Hypertension and Allows Differentiation of the Type of Pulmonary Hypertension.CTLA-4 表达是特发性肺动脉高压有前途的生物标志物，并可区分肺动脉高压的类型。
Int J Mol Sci. 2022 Dec 14;23(24):15910. doi: 10.3390/ijms232415910.

引用本文的文献

1
Microbiota Transplant Therapy Is Safe and Feasible in Pulmonary Arterial Hypertension.微生物群移植疗法在肺动脉高压中是安全可行的。
JACC Basic Transl Sci. 2025 Aug 12;10(9):101347. doi: 10.1016/j.jacbts.2025.101347.
2
Plasma IL4 Levels Linked to Pulmonary Hypertension Severity and Outcome.血浆白细胞介素4水平与肺动脉高压的严重程度及预后相关。
Clin Exp Pharmacol Physiol. 2025 Jun;52(6):e70040. doi: 10.1111/1440-1681.70040.
3
Changes in Macrophages in Pulmonary Hypertension: A Focus on High-altitude Pulmonary Hypertension.肺动脉高压中巨噬细胞的变化：聚焦于高原肺动脉高压

本文引用的文献

1
CTLA-4 Expression Is a Promising Biomarker of Idiopathic Pulmonary Arterial Hypertension and Allows Differentiation of the Type of Pulmonary Hypertension.CTLA-4 表达是特发性肺动脉高压有前途的生物标志物，并可区分肺动脉高压的类型。
Int J Mol Sci. 2022 Dec 14;23(24):15910. doi: 10.3390/ijms232415910.
2
2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension.2022年欧洲心脏病学会/欧洲呼吸学会肺动脉高压诊断和治疗指南。
Eur Heart J. 2022 Oct 11;43(38):3618-3731. doi: 10.1093/eurheartj/ehac237.
3
Peripheral Blood T Cells of Patients with IPAH Have a Reduced Cytokine-Producing Capacity.
Anatol J Cardiol. 2025 Mar 10;29(5):210-21. doi: 10.14744/AnatolJCardiol.2025.5013.
4
Post-transcriptional regulation of IFI16 promotes inflammatory endothelial pathophenotypes observed in pulmonary arterial hypertension.IFI16的转录后调控促进了肺动脉高压中观察到的炎症性内皮病理表型。
Am J Physiol Lung Cell Mol Physiol. 2025 Jan 1;328(1):L148-L158. doi: 10.1152/ajplung.00048.2024. Epub 2024 Dec 10.
5
Post-transcriptional regulation of IFI16 promotes inflammatory endothelial pathophenotypes observed in pulmonary arterial hypertension.IFI16的转录后调控促进了肺动脉高压中观察到的炎症性内皮病理表型。
bioRxiv. 2024 Sep 20:2024.09.19.613988. doi: 10.1101/2024.09.19.613988.
6
Connexin43, A Promising Target to Reduce Cardiac Arrhythmia Burden in Pulmonary Arterial Hypertension.缝隙连接蛋白 43：降低肺动脉高压性心律失常负担的有前途靶点
Int J Mol Sci. 2024 Mar 14;25(6):3275. doi: 10.3390/ijms25063275.
特发性肺动脉高压患者的外周血 T 细胞产生细胞因子的能力降低。
Int J Mol Sci. 2022 Jun 10;23(12):6508. doi: 10.3390/ijms23126508.
4
Priming of microglia by type II interferon is lasting and resistant to modulation by interleukin-10 in situ.Ⅱ型干扰素对小胶质细胞的启动作用是持久的，并能抵抗局部白细胞介素-10的调节。
J Neuroimmunol. 2022 Jul 15;368:577881. doi: 10.1016/j.jneuroim.2022.577881. Epub 2022 Apr 28.
5
Role of the Immune System Elements in Pulmonary Arterial Hypertension.免疫系统元件在肺动脉高压中的作用
J Clin Med. 2021 Aug 23;10(16):3757. doi: 10.3390/jcm10163757.
6
Plasma markers in pulmonary hypertension subgroups correlate with patient survival.肺高血压亚组中的血浆标志物与患者生存率相关。
Respir Res. 2021 May 4;22(1):137. doi: 10.1186/s12931-021-01716-w.
7
Overexpression of PD-1 on Peripheral Blood Lymphocytes in Patients with Idiopathic Pulmonary Arterial Hypertension and Its Association with High Viral Loads of Epstein-Barr Virus and Poor Clinical Parameters.特发性肺动脉高压患者外周血淋巴细胞上PD-1的过表达及其与爱泼斯坦-巴尔病毒高病毒载量和不良临床参数的关联
J Clin Med. 2020 Jun 24;9(6):1966. doi: 10.3390/jcm9061966.
8
Cytokines in Inflammatory Disease.细胞因子与炎症性疾病
Int J Mol Sci. 2019 Nov 28;20(23):6008. doi: 10.3390/ijms20236008.
9
Pulmonary arterial hypertension: pathogenesis and clinical management.肺动脉高压：发病机制与临床管理
BMJ. 2018 Mar 14;360:j5492. doi: 10.1136/bmj.j5492.
10
A cellular and molecular view of T helper 17 cell plasticity in autoimmunity.辅助性 T 细胞 17 细胞可塑性在自身免疫中的细胞和分子研究。
J Autoimmun. 2018 Feb;87:1-15. doi: 10.1016/j.jaut.2017.12.007. Epub 2017 Dec 22.