Su Jingqian, Tan Qingqing, Wu Shun, Abbas Bilal, Yang Minhe
Fujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, College of Life Science, Fujian Normal University, Fuzhou 350117, China.
Fujian Key Laboratory of Microbial Pathogenesis and Interventions-Fujian Province University, Biomedical Research Center of South China, College of Life Science, Fujian Normal University, Fuzhou 350117, China.
Int J Mol Sci. 2023 Sep 12;24(18):13984. doi: 10.3390/ijms241813984.
Treatment for sepsis and its complications in the clinic is primarily in the forms of antibiotics, anti-inflammatory agents, and antioxidant drugs. Kombucha, a traditional fermented beverage rich in tea polyphenols and organic acids, offers several benefits including bacteriostasis, anti-inflammation ability, and boosting the immune system. Currently, research on kombucha is primarily focused on its antibacterial and antioxidant properties; however, in-depth exploration of the involved mechanisms is lacking. Herein, turmeric, , and black tea were used as fermentation substrates to detect the bacteriostatic and antioxidant activities of the fermentation broth and evaluate its anti-inflammatory effects on RAW264.7 cells stimulated by lipopolysaccharides (LPSs). The results showed that fermentation enhanced the antibacterial activity of turmeric against and and that of against . Turmeric black tea exhibited the highest antioxidant activity. The fermentation broth of turmeric and turmeric black tea significantly reduced the expression of inflammatory cytokines induced by LPSs. Our results showed that using turmeric and culture media as substrates can enhance the anti-inflammatory effects of fermentation broth and provide a new strategy for developing anti-inflammatory substances.
临床上治疗败血症及其并发症主要采用抗生素、抗炎药和抗氧化药物。康普茶是一种富含茶多酚和有机酸的传统发酵饮料，具有多种益处，包括抑菌、抗炎能力和增强免疫系统。目前，对康普茶的研究主要集中在其抗菌和抗氧化特性上；然而，缺乏对相关机制的深入探索。在此，以姜黄、[此处原文缺失内容]和红茶作为发酵底物，检测发酵液的抑菌和抗氧化活性，并评估其对脂多糖（LPSs）刺激的RAW264.7细胞的抗炎作用。结果表明，发酵增强了姜黄对[此处原文缺失内容]和[此处原文缺失内容]的抗菌活性以及[此处原文缺失内容]对[此处原文缺失内容]的抗菌活性。姜黄红茶表现出最高的抗氧化活性。姜黄和姜黄红茶的发酵液显著降低了LPSs诱导的炎性细胞因子的表达。我们的结果表明，以姜黄和[此处原文缺失内容]培养基为底物可以增强发酵液的抗炎作用，并为开发抗炎物质提供了一种新策略。
