Palmrich Pilar, Schirwani-Hartl Nawa, Haberl Christina, Haslinger Peter, Heinzl Florian, Zeisler Harald, Binder Julia
Department of Obstetrics and Gynecology, Division of Obstetrics and Feto-Maternal Medicine, Medical University of Vienna, 1090 Vienna, Austria.
J Clin Med. 2023 Sep 12;12(18):5931. doi: 10.3390/jcm12185931.
Catestatin has been identified as an important factor in blood pressure control in non-pregnant adults. A possible impact on the development of hypertensive disorders of pregnancy has been indicated. Data on catestatin levels in pregnancy are scarce. The aim of this study was to investigate a potential association of maternal serum catestatin levels to the pathogenesis of preeclampsia.
We evaluated serum catestatin levels of 50 preeclamptic singleton pregnancies and 50 healthy gestational-age-matched pregnancies included in the obstetric biobank registry of the Medical University of Vienna. Receiver operating characteristic curves and logistic regression models were performed to investigate an association between catestatin levels and development of preeclampsia.
Catestatin levels were significantly decreased in women with preeclampsia compared to healthy controls (median CST: 3.03 ng/mL, IQR [1.24-7.21 ng/mL] vs. 4.82 ng/mL, IQR [1.82-10.02 ng/mL]; = 0.010), indicating an association between decreased catestatin values and the development of preeclampsia. There was no significant difference in catestatin values between early-onset preeclampsia and late-onset preeclampsia. Modelling the occurrence of preeclampsia via logistic regression was improved when adding catestatin as a predictive factor.
Decreased serum catestatin levels are associated with the presence of preeclampsia. Further investigations into the diagnostic value and possible therapeutic role of catestatin in preeclampsia are warranted.
抑胃肽已被确认为非妊娠成年人血压控制中的一个重要因素。有迹象表明其可能对妊娠期高血压疾病的发展产生影响。关于孕期抑胃肽水平的数据很少。本研究的目的是调查孕妇血清抑胃肽水平与子痫前期发病机制之间的潜在关联。
我们评估了维也纳医科大学产科生物样本库登记的50例子痫前期单胎妊娠和50例孕周匹配的健康妊娠的血清抑胃肽水平。采用受试者工作特征曲线和逻辑回归模型来研究抑胃肽水平与子痫前期发生之间的关联。
与健康对照组相比，子痫前期女性的抑胃肽水平显著降低（抑胃肽中位数：3.03 ng/mL，四分位间距[IQR][1.24 - 7.21 ng/mL] 对比4.82 ng/mL，IQR [1.82 - 10.02 ng/mL]；P = 0.010），表明抑胃肽值降低与子痫前期的发生有关。早发型子痫前期和晚发型子痫前期的抑胃肽值无显著差异。将抑胃肽作为预测因素加入逻辑回归模型后，子痫前期发生情况的模型拟合得到改善。
血清抑胃肽水平降低与子痫前期的存在有关。有必要进一步研究抑胃肽在子痫前期中的诊断价值和可能的治疗作用。
