骨质疏松症作为一名16岁瘦小男孩库欣病的首发症状——病例报告

Łupińska Anna, Aszkiełowicz Sara, Zieliński Grzegorz, Stawerska Renata, Lewiński Andrzej

Department of Paediatric Endocrinology, Medical University of Lodz, 93-338 Lodz, Poland.

Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital-Research Institute, 93-338 Lodz, Poland.

J Clin Med. 2023 Sep 14;12(18):5967. doi: 10.3390/jcm12185967.

Cushing's disease (CD) is an extremely rare diagnosis in children. In this report, we present the case of an almost 16-year-old, short and thin boy with CD, the first symptoms of which were spinal pain and vertebral fractures as a result of osteoporosis. In light of his growth retardation and short stature, the boy underwent diagnostics, which excluded growth hormone (GH) deficiency, hypothyroidism and celiac disease. Finally, based on cortisol profile results, dexamethasone suppression tests and bilateral sampling during catheterization of the inferior petrosal sinuses, CD was diagnosed.

库欣病（CD）在儿童中是一种极其罕见的诊断。在本报告中，我们介绍了一名近16岁、身材瘦小的患有库欣病的男孩，其最初症状是由于骨质疏松导致的脊柱疼痛和椎体骨折。鉴于他生长发育迟缓及身材矮小，该男孩接受了诊断检查，排除了生长激素（GH）缺乏、甲状腺功能减退和乳糜泻。最后，根据皮质醇水平检测结果、地塞米松抑制试验以及岩下窦插管时的双侧采样，确诊为库欣病。