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肥胖症的手术治疗能否治愈女性尿失禁?一项前瞻性单中心研究。

Is Surgical Treatment for Obesity Able to Cure Urinary Incontinence in Women?-A Prospective Single-Center Study.

作者信息

Persu Cristian, Cartas Remus Nicolae, Ciofu Irina, Mastalier Bogdan, Cauni Victor Mihail

机构信息

Department of Urology, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Department of Urology, Colentina Clincal Hospital, 020125 Bucharest, Romania.

出版信息

Life (Basel). 2023 Sep 11;13(9):1897. doi: 10.3390/life13091897.

DOI:10.3390/life13091897
PMID:37763301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10533078/
Abstract

There is enough evidence to support weight loss in order to improve urinary incontinence. Nevertheless, weight loss and maintaining a lower weight are not easy to achieve in the general population. Our study aims to evaluate whether bariatric surgery has a positive effect on the symptoms of urinary incontinence in female patients. We performed a prospective study on obese female patients before and after bariatric surgery, over a period of 9 years. Patients with a BMI ≥ 33 kg/m were included if they described involuntary loss of urine and no previous surgery for urinary incontinence was performed. The patients underwent laparoscopic surgery, either gastric sleeve, bypass or banding, performed by four surgeons in our hospital. The type of incontinence was not assessed at the initial visit carried out by the surgeon. All patients who declared being incontinent were referred to the urologist where they received the ICIQ-UI-SF questionnaire before their bariatric surgery and during follow -up visits. The sum of points obtained at questions 3, 4 and 5 was used to evaluate the severity of incontinence, as well as the impact on the quality of life. Our evaluation collected data on age, time since onset of symptoms, pad usage, number and type of deliveries, concomitant conditions and medications. The type of incontinence was assessed by the urologist before bariatric surgery as urge, stress or mixed incontinence. At follow-up visits, the patients were also asked to fill out a 10-point VAS questionnaire evaluating their perception on the evolution of incontinence symptoms. Data were analyzed using -test statistical analysis. Our objective defined changes in incontinence as cure, improved, no change and worse. We included 54 women from whom initial data and at least 18 months of follow-up were available. We observed that about 50% of all women undergoing bariatric surgery have some degree of urinary incontinence. The ICIQ score improved from 13.31 ± 5.18 before surgery to 8.30 ± 4.49 points after surgery ( < 0.0001). Before surgery, 38 patients (70%) described severe incontinence compared to only 20 patients (37%) after surgery. A total of 16 women (31%) reported complete cure of urinary incontinence after bariatric surgery. Data from the VAS questionnaire show improvement in 46 cases (85%). Pad usage improved from 7.04 ± 2.79 to 3.42 ± 2.77 ( < 0.001) per day. The number of patients using more than one pad per day decreased from 35 (65%) to 9 (17%). The type of incontinence did not seem to be relevant, but our sample size was too small to lead to statistically significant results. There was no impact on the outcome of incontinence of number/type of delivery, age or BMI. Our data show that bariatric surgery is able to cure urinary incontinence in one of three obese women. A significant improvement was obtained in more than two-thirds of the patients, regardless of the type of incontinence. For an obese female with urinary incontinence, treatment for obesity should prevail and incontinence should be treated only if symptoms remain.

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfa4/10533078/b5d2086a471c/life-13-01897-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfa4/10533078/b5d2086a471c/life-13-01897-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfa4/10533078/b5d2086a471c/life-13-01897-g001.jpg
摘要

有足够的证据支持通过减肥来改善尿失禁。然而,在普通人群中,减肥并维持较低体重并非易事。我们的研究旨在评估减肥手术对女性尿失禁患者症状是否有积极影响。我们对肥胖女性患者在减肥手术前后进行了为期9年的前瞻性研究。如果BMI≥33kg/m²且自述有尿液不自主流失且此前未接受过尿失禁手术的患者被纳入研究。患者接受了由我院四名外科医生进行的腹腔镜手术,术式包括胃袖状切除术、胃旁路术或胃束带术。外科医生在初次就诊时未评估失禁类型。所有自述有失禁症状的患者均被转诊至泌尿科医生处,在减肥手术前及随访期间接受ICIQ-UI-SF问卷评估。问题3、4和5的得分总和用于评估失禁的严重程度以及对生活质量的影响。我们的评估收集了患者的年龄、症状出现时间、护垫使用情况、分娩次数及类型、伴随疾病和用药情况等数据。泌尿科医生在减肥手术前评估失禁类型为急迫性、压力性或混合性失禁。在随访时,还要求患者填写一份10分的视觉模拟量表(VAS)问卷以评估他们对失禁症状演变的感知。数据采用t检验统计分析。我们将失禁的变化定义为治愈、改善、无变化和恶化。我们纳入了54名有初始数据且至少有18个月随访资料的女性。我们观察到,所有接受减肥手术的女性中约50%有某种程度的尿失禁。ICIQ评分从术前的13.31±5.18分提高到术后的8.30±4.49分(P<0.0001)。术前,38名患者(70%)自述有严重失禁,而术后只有20名患者(37%)。共有16名女性(31%)报告减肥手术后尿失禁完全治愈。VAS问卷数据显示46例(85%)有改善。护垫使用量从每天7.04±2.79片降至3.42±2.77片(P<0.001)。每天使用不止一片护垫的患者人数从35名(65%)降至9名(17%)。失禁类型似乎无关紧要,但我们的样本量太小,无法得出具有统计学意义的结果。分娩次数/类型、年龄或BMI对失禁结局没有影响。我们的数据表明,减肥手术能使三分之一的肥胖女性尿失禁得到治愈。超过三分之二的患者有显著改善,无论失禁类型如何。对于有尿失禁的肥胖女性,应优先治疗肥胖,只有症状持续时才治疗失禁。

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Solifenacin Treatment After Intradetrusor Injections With Botulinum Toxin in Patients With Neurogenic Detrusor Overactivity.在神经源性逼尿肌过度活动患者中,经尿道注射肉毒毒素后应用索利那新治疗。
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