Martin Raul
Instituto Universitario de Oftalmobiología Aplicada (IOBA), Universidad de Valladolid, Paseo de Belén, 17-Campus Miguel Delibes, 47011 Valladolid, Spain.
Life (Basel). 2023 Sep 21;13(9):1941. doi: 10.3390/life13091941.
Patient-reported dry eye symptoms (DESs), assessed using the Ocular Surface Disease Index (OSDI) and the Symptom Assessment iN Dry Eye (SANDE) questionnaires, were compared in a large sample of patients.
The correlation (Spearman coefficient) and agreement (Bland-Altman analysis) between the OSDI and SANDE questionnaire scores (with and without score normalization) were assessed in 1033 patients and classified according to the OSDI score as non-DES and DES in a cross-sectional analysis.
The normalized and non-normalized SANDE results were higher than the OSDI results in all samples (2.83 ± 12.40 ( = 0.063) and 2.85 ± 15.95 ( = 0.016), respectively) and in non-DES ( > 0.063) and DES ( < 0.001) with both OSDI cutoff values. Weak correlations were found (Spearman coefficient <0.53; < 0.001) in all cases except DES (0.12, = 0.126). Weak agreement was found with a Bland-Altman analysis of the normalized and non-normalized scores of both questionnaires (mean difference from -7.67 ± 29.17 (DES patients) to -1.33 ± 8.99 (non-DES patients) without score normalization, and from -9.21 ± 26.37 (DES patients) to -0.85 ± 4.01 (non-DES) with data normalization), with a statistically significant linear relationship (R > 0.32, < 0.001). The SANDE questionnaire did not yield the same patient classification as OSDI. The same operative curves (ROC) of the SANDE normalized and non-normalized scores were used to differentiate among patients with DES using OSDI < 12 (0.836 ± 0.015) or OSDI < 22 (0.880 ± 0.015) cutoff values.
Normalized and non-normalized data collected from the SANDE questionnaire showed relevant differences from those of the OSDI, which suggests that the results of the SANDE visual analog scale-based questionnaire provide different patient classifications than the OSDI score.
在大量患者样本中，比较了使用眼表疾病指数（OSDI）和干眼症状评估问卷（SANDE）评估的患者报告的干眼症状（DESs）。
在1033例患者中评估了OSDI和SANDE问卷评分（有和没有分数标准化）之间的相关性（Spearman系数）和一致性（Bland-Altman分析），并在横断面分析中根据OSDI评分分为非DES和DES。
在所有样本中，标准化和未标准化的SANDE结果均高于OSDI结果（分别为2.83±12.40（=0.063）和2.85±15.95（=0.016）），在非DES（>0.063）和DES（<0.001）中，两种OSDI临界值均如此。除DES（0.12，=0.126）外，所有情况下均发现弱相关性（Spearman系数<0.53；<0.001）。对两种问卷的标准化和未标准化分数进行Bland-Altman分析发现一致性较弱（平均差异从-7.67±29.17（DES患者）到-1.33±8.99（非DES患者），无分数标准化，以及从-9.21±26.37（DES患者）到-0.85±4.01（非DES），数据标准化），具有统计学显著的线性关系（R>0.32，<0.001）。SANDE问卷没有产生与OSDI相同的患者分类。使用SANDE标准化和未标准化分数的相同手术曲线（ROC）来区分OSDI<12（0.836±0.015）或OSDI<22（0.880±0.015）临界值的DES患者。
从SANDE问卷收集的标准化和未标准化数据显示与OSDI的数据存在相关差异，这表明基于SANDE视觉模拟量表的问卷结果提供了与OSDI评分不同的患者分类。
