微生物群在风湿性心脏病中的免疫调节作用：我们知道什么以及能从其他风湿性疾病中学到什么？
The Immunomodulatory Role of Microbiota in Rheumatic Heart Disease: What Do We Know and What Can We Learn from Other Rheumatic Diseases?
作者信息
Kohil Amira, Abdalla Wafa, Ibrahim Wisam N, Al-Harbi Khalid M, Al-Haidose Amal, Al-Asmakh Maha, Abdallah Atiyeh M
机构信息
Division of Biological and Biomedical Sciences, College of Health and Life Sciences, Hamad Bin Khalifa University, Doha 34110, Qatar.
Department of Biomedical Sciences, College of Health Sciences, QU-Health, Qatar University, Doha 2713, Qatar.
出版信息
Medicina (Kaunas). 2023 Sep 8;59(9):1629. doi: 10.3390/medicina59091629.
Rheumatic heart disease (RHD) represents a serious cardiac sequela of acute rheumatic fever, occurring in 30-45% of patients. RHD is multifactorial, with a strong familial predisposition and known environmental risk factors that drive loss of immunological tolerance. The gut and oral microbiome have recently been implicated in the pathogenesis of RHD. Disruption of the delicate balance of the microbiome, or dysbiosis, is thought to lead to autoimmune responses through several different mechanisms including molecular mimicry, epitope spreading, and bystander activation. However, data on the microbiomes of RHD patients are scarce. Therefore, in this comprehensive review, we explore the various dimensions of the intricate relationship between the microbiome and the immune system in RHD and other rheumatic diseases to explore the potential effect of microbiota on RHD and opportunities for diagnosis and treatment.
风湿性心脏病（RHD）是急性风湿热严重的心脏后遗症，30%-45%的患者会出现该疾病。RHD是多因素导致的，具有很强的家族易感性以及已知的环境风险因素，这些因素会导致免疫耐受性丧失。肠道和口腔微生物群最近被认为与RHD的发病机制有关。微生物群微妙平衡的破坏，即生态失调，被认为会通过多种不同机制引发自身免疫反应，包括分子模拟、表位扩展和旁观者激活。然而，关于RHD患者微生物群的数据很少。因此，在这篇全面综述中，我们探讨了RHD和其他风湿性疾病中微生物群与免疫系统之间复杂关系的各个方面，以探究微生物群对RHD的潜在影响以及诊断和治疗的机会。
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