Gallenga Carla Enrica, Maritati Martina, Mura Marco, Di Virgilio Francesco, Conti Pio, Contini Carlo
Department of Medical Sciences Doctoral Course Molecular Medicine, University of Ferrara, 44121 Ferrara, Italy.
Ophthalmology Unit, University-Hospital Cona, 44124 Ferrara, Italy.
Microorganisms. 2023 Aug 31;11(9):2198. doi: 10.3390/microorganisms11092198.
Among the symptoms of SARS-CoV-2, follicular conjunctivitis has become relevant. The conjunctiva acts as an open lymph node, reacting to the viral antigen that binds the epithelial cells, forming follicles of B cells with activated T cells and NK cells on its surface, which, in turn, talk to monocyte-derived inflammatory infected macrophages. Here, the NLRP3 inflammasome is a major driver in releasing pro-inflammatory factors such as IL-6 and caspase-1, leading to follicular conjunctivitis and bulbar congestion, even as isolated signs in the 'asymptomatic' patient.
在新型冠状病毒肺炎（SARS-CoV-2）的症状中，滤泡性结膜炎已变得较为常见。结膜起着开放淋巴结的作用，对与上皮细胞结合的病毒抗原作出反应，在其表面形成含有活化T细胞和自然杀伤（NK）细胞的B细胞滤泡，而这些细胞又与单核细胞衍生的炎性感染巨噬细胞相互作用。在此，NLRP3炎性小体是释放白细胞介素-6（IL-6）和半胱天冬酶-1等促炎因子的主要驱动因素，可导致滤泡性结膜炎和球结膜充血，甚至在“无症状”患者中也可作为单独的体征出现。
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