应激、微生物群落失调及炎症对坏死性小肠结肠炎的影响
The Impact of Stress, Microbial Dysbiosis, and Inflammation on Necrotizing Enterocolitis.
作者信息
Yeramilli Venkata, Cheddadi Riadh, Benjamin Heather, Martin Colin
机构信息
Division of Pediatric, Department of Surgery, University of Alabama at Birmingham, 1600 7th Ave. S., Lowder Building Suite 300, Birmingham, AL 35233, USA.
出版信息
Microorganisms. 2023 Aug 31;11(9):2206. doi: 10.3390/microorganisms11092206.
Abstract
Necrotizing enterocolitis (NEC) is the leading cause of intestinal morbidity and mortality in neonates. A large body of work exists; however, the pathogenesis of NEC remains poorly understood. Numerous predictors have been implicated in the development of NEC, with relatively less emphasis on maternal factors. Utilizing human tissue plays a crucial role in enhancing our comprehension of the underlying mechanisms accountable for this devastating disease. In this review, we will discuss how maternal stress affects the pathogenesis of NEC and how changes in the intestinal microbiome can influence the development of NEC. We will also discuss the results of transcriptomics-based studies and analyze the gene expression changes in NEC tissues and other molecular targets associated with the pathogenesis of NEC.
摘要
坏死性小肠结肠炎（NEC）是新生儿肠道发病和死亡的主要原因。虽然已有大量相关研究，但NEC的发病机制仍未完全明确。许多因素被认为与NEC的发生有关，其中对母体因素的关注相对较少。利用人体组织对于加深我们对这种毁灭性疾病潜在机制的理解起着关键作用。在本综述中，我们将讨论母体应激如何影响NEC的发病机制，以及肠道微生物群的变化如何影响NEC的发展。我们还将讨论基于转录组学的研究结果，并分析NEC组织中的基因表达变化以及与NEC发病机制相关的其他分子靶点。
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