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Preparation of Herbal Extracts for Intestinal Immune Modulation Activity Based on Screening and Evaluation of Rosc. Extracts.

作者信息

Min Su Ji, Kim Sung Jin, Park Jun Yeon, Seo Chang-Seob, Choi You-Kyong

机构信息

College of Korean Medicine, Gachon University, Seongnam 13120, Republic of Korea.

Department of Food Science and Biotechnology, Kyonggi University, Suwon 16227, Republic of Korea.

出版信息

Molecules. 2023 Sep 21;28(18):6743. doi: 10.3390/molecules28186743.

DOI:10.3390/molecules28186743
PMID:37764519
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10536359/
Abstract

Ten traditional herbal extracts effective against diarrhea, infectious diseases, and bacterial activity were selected and analyzed for Peyer's patch cell-mediated intestinal immunomodulatory activity and . Among the 10 herbal extracts, Rosc. (ZO) extract induced the highest secretion of immunoglobulin A (IgA) and granulocyte macrophage colony-stimulating factor (GM-CSF) in the cells of Peyer's patches. Furthermore, animal experiments showed that IA production was enhanced with the oral administration of ZO extract (100 mg/kg and 300 mg/kg) for 10 days. In addition, 6-, 8-, 10-gingerol, and 6-, 8-, 10-shogaol, the six major index compounds of ZO extract, were analyzed using HPLC. Our study findings confirm the intestinal immunomodulatory activity of ZO extract and lay a strong foundation for future analytical studies aimed at determining the active components of ZO extracts.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ee/10536359/fe772ceb6177/molecules-28-06743-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ee/10536359/04567e71c0d2/molecules-28-06743-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ee/10536359/fdad50cb034f/molecules-28-06743-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ee/10536359/ef67fa010dcd/molecules-28-06743-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ee/10536359/95d684a95e4a/molecules-28-06743-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ee/10536359/2b08020bae2b/molecules-28-06743-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ee/10536359/fe772ceb6177/molecules-28-06743-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ee/10536359/04567e71c0d2/molecules-28-06743-g001a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ee/10536359/fdad50cb034f/molecules-28-06743-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ee/10536359/ef67fa010dcd/molecules-28-06743-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ee/10536359/95d684a95e4a/molecules-28-06743-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ee/10536359/2b08020bae2b/molecules-28-06743-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30ee/10536359/fe772ceb6177/molecules-28-06743-g006.jpg

相似文献

[1]
Preparation of Herbal Extracts for Intestinal Immune Modulation Activity Based on Screening and Evaluation of Rosc. Extracts.

Molecules. 2023-9-21

[2]
Ameliorative Effects of Rosc on Antibiotic-Associated Diarrhea and Improvement in Intestinal Function.

Molecules. 2024-2-5

[3]
Enhanced production of hematopoietic growth factors through T cell activation in Peyer's patches by oral administration of Kampo (Japanese herbal) medicine, "Juzen-Taiho-To".

Phytomedicine. 1998-10

[4]
Lactic Acid Bacteria Improves Peyer's Patch Cell-Mediated Immunoglobulin A and Tight-Junction Expression in a Destructed Gut Microbial Environment.

J Microbiol Biotechnol. 2016-6-28

[5]
Peyer's patch-immunomodulating glucans from sugar cane enhance protective immunity through stimulation of the hemopoietic system.

Int J Biol Macromol. 2018-11-22

[6]
Mucosal immunomodulatory evaluation and chemical profile elucidation of a classical traditional Chinese formula, Bu-Zhong-Yi-Qi-Tang.

J Ethnopharmacol. 2018-9-6

[7]
Enhanced Intestinal Immune Response in Mice after Oral Administration of Korea Red Ginseng-Derived Polysaccharide.

Polymers (Basel). 2020-9-24

[8]
Analysis of T cell and B cell function in Peyer's patch and lamina propria of New Zealand Black and DBA/2 mice.

J Immunol. 1986-6-1

[9]
Polysaccharide-Containing Macromolecules in a Kampo (Traditional Japanese Herbal) Medicine, Hochuekkito: Dual Active Ingredients for Modulation of Immune Functions on Intestinal Peyer's Patches and Epithelial cells.

Evid Based Complement Alternat Med. 2011-3-10

[10]
S-1-Propenylcysteine promotes the differentiation of B cells into IgA-producing cells by the induction of Erk1/2-dependent Xbp1 expression in Peyer's patches.

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引用本文的文献

[1]
The Bioactivity and Phytochemicals of (), a Plant of Multiple Pharmacological Activities.

Int J Mol Sci. 2024-2-23

[2]
Ameliorative Effects of Rosc on Antibiotic-Associated Diarrhea and Improvement in Intestinal Function.

Molecules. 2024-2-5

本文引用的文献

[1]
Beneficial Effect of Paeonol on Antibiotic-Associated Inflammatory Response in Mice with Diarrhea.

Biomolecules. 2022-11-3

[2]
Enhanced Intestinal Immune Response in Mice after Oral Administration of Korea Red Ginseng-Derived Polysaccharide.

Polymers (Basel). 2020-9-24

[3]
The Effects of Secretory IgA in the Mucosal Immune System.

Biomed Res Int. 2020-1-3

[4]
IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches.

Science. 2016-5-13

[5]
Peyer's patches: organizing B-cell responses at the intestinal frontier.

Immunol Rev. 2016-5

[6]
Lactic Acid Bacteria Improves Peyer's Patch Cell-Mediated Immunoglobulin A and Tight-Junction Expression in a Destructed Gut Microbial Environment.

J Microbiol Biotechnol. 2016-6-28

[7]
Peyer's patch-mediated intestinal immune system modulating activity of pectic-type polysaccharide from peel of Citrus unshiu.

Food Chem. 2012-11-29

[8]
Enhanced production of hematopoietic growth factors through T cell activation in Peyer's patches by oral administration of Kampo (Japanese herbal) medicine, "Juzen-Taiho-To".

Phytomedicine. 1998-10

[9]
The mucosal immune system of the respiratory tract.

Curr Opin Virol. 2012-4-25

[10]
Peyer's Patches: The Immune Sensors of the Intestine.

Int J Inflam. 2010-9-19

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