分泌型免疫球蛋白 A 在黏膜免疫系统中的作用。
The Effects of Secretory IgA in the Mucosal Immune System.
机构信息
Department of Rheumatology/Immunology, Children's National Medical Center, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Division of Immunology, Institute of Pediatric Translational Medicine, Children's National Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
出版信息
Biomed Res Int. 2020 Jan 3;2020:2032057. doi: 10.1155/2020/2032057. eCollection 2020.
Abstract
Immunoglobulin A (IgA) is the most abundant antibody isotype in the mucosal immune system. Structurally, IgA in the mucosal surface is a polymeric structure, while serum IgA is monomeric. Secretory IgA (sIgA) is one of the polymeric IgAs composed of dimeric IgA, J chain, and secretory component (SC). Most of sIgAs were generated by gut and have effects in situ. Besides the function of "immune exclusion," a nonspecific immune role, recent studies found it also played an important role in the specific immunity and immunoregulation. Thanks to the critical role of sIgA during the mucosal immune system homeostasis between commensal microorganisms and pathogens; it has been an important field exploring the relationship between sIgA and commensal microorganisms.
摘要
免疫球蛋白 A（IgA）是黏膜免疫系统中含量最多的抗体同种型。从结构上看，黏膜表面的 IgA 是多聚体结构，而血清 IgA 是单体。分泌型 IgA（sIgA）是由二聚体 IgA、J 链和分泌成分（SC）组成的多聚 IgA 之一。大多数 sIgA 由肠道产生，具有局部作用。除了“免疫排除”的功能（一种非特异性免疫作用）外，最近的研究发现它在特异性免疫和免疫调节中也起着重要作用。由于 sIgA 在黏膜免疫系统中对共生微生物和病原体之间的稳态的关键作用；它一直是探索 sIgA 与共生微生物之间关系的重要领域。
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