Møller D, Ipsen L, Asschenfeldt P
Acta Obstet Gynecol Scand. 1986;65(5):501-2. doi: 10.3109/00016348609157393.
The first case in Denmark of malignant melanoma metastasizing to the placenta and the fetal circulation is presented. The fact that shortly before becoming pregnant the patient had been treated with wide excision and regional lymph node dissection for a cutaneous melanoma of the right calf, gives further support to suspicions about a possible adverse effect of pregnancy on melanoma. In view of the high mortality in babies during their first year of life in the few similar reports available in the world literature, the authors would recommend the avoidance of pregnancy within 5 years of treatment of melanoma of any stage.
本文报道了丹麦首例恶性黑色素瘤转移至胎盘及胎儿循环系统的病例。该患者在怀孕前不久曾因右小腿皮肤黑色素瘤接受了广泛切除及区域淋巴结清扫术，这一事实进一步支持了关于妊娠可能对黑色素瘤产生不良影响的怀疑。鉴于世界文献中少数类似报道显示婴儿出生后第一年死亡率较高，作者建议在任何阶段黑色素瘤治疗后的5年内避免妊娠。
