基于壳聚糖的自愈合水凝胶：从制备到生物医学应用

Pan Siyu, Zhu Chongyu, Wu Yuwei, Tao Lei

The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China.

Key Laboratory of Science and Technology of Eco-Textile, Ministry of Education, College of Chemistry and Chemical Engineering, Donghua University, Shanghai 201620, China.

Polymers (Basel). 2023 Sep 14;15(18):3768. doi: 10.3390/polym15183768.

Biocompatible self-healing hydrogels are new-generation smart soft materials that hold great promise in biomedical fields. Chitosan-based self-healing hydrogels, mainly prepared via dynamic imine bonds, have attracted broad attention due to their mild preparation conditions, excellent biocompatibility, and self-recovery ability under a physiological environment. In this review, we present a comprehensive overview of the design and fabrication of chitosan-based self-healing hydrogels, and summarize their biomedical applications in tissue regeneration, customized drug delivery, smart biosensors, and three/four dimensional (3D/4D) printing. Finally, we will discuss the challenges and future perspectives for the development of chitosan-based self-healing hydrogels in the biomedical field.

生物相容性自愈水凝胶是新一代智能软材料，在生物医学领域具有广阔前景。基于壳聚糖的自愈水凝胶主要通过动态亚胺键制备，因其制备条件温和、生物相容性优异以及在生理环境下的自我修复能力而受到广泛关注。在本综述中，我们全面概述了基于壳聚糖的自愈水凝胶的设计与制备，并总结了它们在组织再生、定制药物递送、智能生物传感器以及三维/四维（3D/4D）打印方面的生物医学应用。最后，我们将讨论基于壳聚糖的自愈水凝胶在生物医学领域发展面临的挑战和未来前景。