基于亚胺键的可注射自修复壳聚糖水凝胶：设计与治疗应用。
Injectable and Self-Healing Chitosan Hydrogel Based on Imine Bonds: Design and Therapeutic Applications.
机构信息
The Key Laboratory of Bioorganic Phosphorus Chemistry Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 10084, China.
Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology, School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China.
出版信息
Int J Mol Sci. 2018 Jul 27;19(8):2198. doi: 10.3390/ijms19082198.
Biological tissues can automatically repair themselves after damage. Examples include skin, muscle, soft tissue, etc. Inspired by these living tissues, numerous self-healing hydrogels have been developed recently. Chitosan-based self-healing hydrogels constructed via dynamic imine bonds have been widely studied due to their simple preparation, good biocompatibility, and automatic reparability under physiological conditions. In this mini-review, we highlighted chitosan-based self-healing hydrogels based on dynamic imine chemistry, and provided an overview of the preparation of these hydrogels and their bioapplications in cell therapy, tumor therapy, and wound healing.
生物组织在受损后能够自动修复。例如皮肤、肌肉、软组织等。受这些活体组织的启发，最近已经开发出许多自修复水凝胶。基于壳聚糖的自修复水凝胶通过动态亚胺键构建，由于其制备简单、良好的生物相容性以及在生理条件下的自动修复性而得到了广泛的研究。在这篇综述中，我们重点介绍了基于动态亚胺化学的壳聚糖基自修复水凝胶，并概述了这些水凝胶的制备及其在细胞治疗、肿瘤治疗和伤口愈合方面的生物应用。
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