定量动态触诱发痛计——一种用于测试慢性肢体疼痛中动态机械性触诱发痛的标准化测量方法。

Quantitative Dynamic Allodynograph-A Standardized Measure for Testing Dynamic Mechanical Allodynia in Chronic Limb Pain.

机构信息

Department of Occupational Therapy, School of Health Professions, Faculty of Medicine, Tel Aviv University, Tel Aviv-Yafo 69978, Israel.

Reuth Rehabilitation Hospital, Tel Aviv-Yafo 6772830, Israel.

出版信息

Sensors (Basel). 2023 Sep 18;23(18):7949. doi: 10.3390/s23187949.

DOI:10.3390/s23187949

PMID:37766006

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10535773/

Abstract

BACKGROUND

Dynamic mechanical allodynia (DMA) is both a symptom and a central sensitization sign, yet no standardized method for quantifying the DMA area has been reported. This study aimed to establish psychometric properties for (), a newly developed protocol measuring the DMA area as a percentage of the body surface.

METHODS

Seventy-eight patients aged 18-65 diagnosed with chronic complex regional pain syndrome (CRPS) participated in this study. Test-retest reliability was conducted twice, one week apart (N = 20), and inter-rater (N = 3) reliability was conducted on 10 participants. Disease severity (, ), pain intensity (VAS), and quality of life (SF-36) measures were utilized to test construct validity.

RESULTS

High inter-rater reliability (intraclass correlation coefficient (ICC) = 0.96, < 0.001) and test-retest reliability ( = 0.98, < 0.001) were found. Furthermore, the QDA score was found to be correlated with the CSS ( = 0.47, < 0.001), VAS ( = 0.37, < 0.001), and the SF-36 physical health total ( = -0.47, < 0.001) scores.

CONCLUSION

The QDA is the first developed reliable and valid protocol for measuring DMA in a clinical setting and may be used as a diagnostic and prognostic measure in clinics and in research, advancing the pain precision medicine approach.

摘要

背景

动态机械性触诱发痛（DMA）既是一种症状，也是一种中枢敏化的标志，但目前尚无量化 DMA 区域的标准化方法。本研究旨在建立一种新的协议（）的心理测量学特性，该协议用于测量 DMA 区域占体表的百分比。

方法

本研究纳入了 78 名年龄在 18-65 岁之间的慢性复杂性区域疼痛综合征（CRPS）患者。采用两次测试（相隔一周，N=20）进行测试-重测信度，对 10 名参与者进行了（N=3）者间信度评估。利用疾病严重程度（，）、疼痛强度（VAS）和生活质量（SF-36）测量来评估构念效度。

结果

发现者间信度（组内相关系数（ICC）=0.96， < 0.001）和测试-重测信度（ = 0.98， < 0.001）均较高。此外，QDA 评分与 CSS（ = 0.47， < 0.001）、VAS（ = 0.37， < 0.001）和 SF-36 身体健康总分（ = -0.47， < 0.001）呈正相关。