Su Lixian, Chen Siyu, Chen Hongbiao, Fang Yuan, Peng Weijun, Zhou Xiaofeng, Luo Jingwei, Liang Xue, Zhang Kechun, Wang Zixin
Department of Child Healthcare, Shenzhen Futian District Maternity & Child Healthcare Hospital, Shenzhen 518016, China.
Centre for Health Behaviours Research, JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Vaccines (Basel). 2023 Aug 22;11(9):1401. doi: 10.3390/vaccines11091401.
This study aimed to investigate the associations between COVID-19 vaccination status and self-reported SARS-CoV-2 infection among children and adolescents aged 3-17 years during a massive COVID-19 outbreak after China changed its zero COVID policy. A cross-sectional online survey was conducted between 1 and 9 March 2023. Participants were the parents of children studying in kindergartens, primary schools, or secondary schools in Shenzhen. Convenient sampling was used. All kindergartens, primary schools, and secondary schools in the Longhua District of Shenzhen invited the parents of children and adolescents attending the schools. Interested parents completed an online survey. Multivariate logistic regression was fitted. Among 8538 participants, 40.9% self-reported that their children had SARS-CoV-2 infection after 7 December 2022, where 92.9% of them received two doses of the COVID-19 vaccines, and 74.6% received their second dose for more than six months. In multivariate analysis, children who received their second dose of the COVID-19 vaccination for no more than three months had a lower SARS-CoV-2 infection rate compared to unvaccinated children (<1 month: AOR: 0.17, 95% CI: 0.07, 0.44; 1-3 months: AOR: 0.54, 95% CI: 0.41, 0.75). The duration of protection conferred by the primary COVID-19 vaccination series was relatively short among children. A booster dose should be considered for children.
本研究旨在调查在中国调整新冠疫情防控政策后，大规模新冠疫情爆发期间3至17岁儿童和青少年的新冠疫苗接种状况与自我报告的SARS-CoV-2感染之间的关联。于2023年3月1日至9日进行了一项横断面在线调查。参与者为在深圳幼儿园、小学或中学就读儿童的家长。采用方便抽样。深圳龙华区的所有幼儿园、小学和中学邀请了在校儿童和青少年的家长。感兴趣的家长完成了一项在线调查。进行了多变量逻辑回归分析。在8538名参与者中，40.9%的家长自我报告其子女在2022年12月7日之后感染了SARS-CoV-2，其中92.9%的儿童接种了两剂新冠疫苗，74.6%的儿童在接种第二剂疫苗后超过六个月。在多变量分析中，与未接种疫苗的儿童相比，接种第二剂新冠疫苗不超过三个月的儿童感染SARS-CoV-2的几率较低（<1个月：比值比：0.17，95%置信区间：0.07，0.
